植物凝集素在生物技术和治疗中的应用:植物凝集素的应用

S. Naik, Sanjit Kumar
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引用次数: 0

摘要

凝集素是一种碳水化合物结合蛋白,广泛应用于各种治疗和生物医学领域。凝集素对多种碳水化合物的不同亲和力引起了生物学家对凝集素功能方面探索的关注。凝集素表达对简单碳水化合物的特异性,如甘露糖、乳糖、唾液酸、复合聚糖和糖蛋白。凝集素根据其糖特异性进行分类,并被用作研究蛋白质-碳水化合物相互作用的工具。凝集素在自然界中无处不在,从细菌、真菌、藻类和动物等各种来源中都可以发现。植物是凝集素最丰富的来源,目前已鉴定出的凝集素有300多种。它们根据需求和功能分布到工厂的各个部分。凝集素在植物中的生理作用尚不清楚。凝集素在植物种子和贮藏组织中的大量存在表明了它们在植物发育中的作用。植物凝集素具有抗菌、抗真菌、杀虫、抗癌、抗利什曼原虫、抗病毒、抗凝血等广泛的活性。本文就植物凝集素的分类及其在生物学各方面的应用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
APPLICATIONS OF PLANT LECTINS IN BIOTECHNOLOGY AND THERAPEUTICS: Plant lectins application
Lectins are carbohydrate-binding proteins broadly used in various therapeutic and biomedical applications. The variable affinity of lectins towards variety of carbohydrates has raised attention for the biologist to explore functional aspects of lectins.  Lectins express specificity to simple carbohydrates for example mannose, lactose, sialic acid, complex glycan, and glycoproteins. Lectins are classified based on their sugar specificity and are used as a tool to study protein-carbohydrate interactions. Lectins are ubiquitous in nature and identified from all sources such as bacteria, fungi, algae, and animals. Plants are the most abundant source of lectins, and till now, more than three hundred lectins were characterized from plants. These are distributed to various parts of a plant according to their requirements and function. The physiological role of lectins in a plant is still not well understood. The overabundant presence of lectins in plant seeds and storage tissues indicated their role in plant development. Plant lectins shows a broad range of activities like antibacterial, antifungal, insecticidal, anticancerous, antileishmanial, antiviral, and anticoagulants. In this review, we aim to highlight the plant lectins classification and their application in various biological aspects.
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