{"title":"尿排泄动力学评价药物吸收。3吸收率计算方法及其在人体四环素吸收中的应用。","authors":"E. Nelson","doi":"10.1002/JPS.3030490709","DOIUrl":null,"url":null,"abstract":"A method was developed to calculate drug absorption rate from urinary excretion rate measurements and applied to study tetracycline absorption in humans after oral ingestion of 25, 50, 100, and 200-mg. doses. Calculation of absorption rate indicated that this drug was absorbed at a rate of about 100 to 140 mg./hr., one hour after 200-mg. doses, and at about 20 to 30 mg./hr., one hour later. Rates at these times decreased when the dose was reduced. Wide individual variation in absorption rate was observed among members of the test panel.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":"35 1","pages":"437-40"},"PeriodicalIF":0.0000,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":"{\"title\":\"Urinary excretion kinetics for evaluation of drug absorption. III. Method for calculation of absorption rate and application to tetracycline absorption in humans.\",\"authors\":\"E. Nelson\",\"doi\":\"10.1002/JPS.3030490709\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A method was developed to calculate drug absorption rate from urinary excretion rate measurements and applied to study tetracycline absorption in humans after oral ingestion of 25, 50, 100, and 200-mg. doses. Calculation of absorption rate indicated that this drug was absorbed at a rate of about 100 to 140 mg./hr., one hour after 200-mg. doses, and at about 20 to 30 mg./hr., one hour later. Rates at these times decreased when the dose was reduced. Wide individual variation in absorption rate was observed among members of the test panel.\",\"PeriodicalId\":17210,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association. American Pharmaceutical Association\",\"volume\":\"35 1\",\"pages\":\"437-40\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association. American Pharmaceutical Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/JPS.3030490709\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/JPS.3030490709","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Urinary excretion kinetics for evaluation of drug absorption. III. Method for calculation of absorption rate and application to tetracycline absorption in humans.
A method was developed to calculate drug absorption rate from urinary excretion rate measurements and applied to study tetracycline absorption in humans after oral ingestion of 25, 50, 100, and 200-mg. doses. Calculation of absorption rate indicated that this drug was absorbed at a rate of about 100 to 140 mg./hr., one hour after 200-mg. doses, and at about 20 to 30 mg./hr., one hour later. Rates at these times decreased when the dose was reduced. Wide individual variation in absorption rate was observed among members of the test panel.
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