MUC1和MUC2糖蛋白在喉癌组织中的表达。

J. Jeannon, V. Aston, F. Stafford, J. Soames, J. Wilson
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引用次数: 11

摘要

本研究的目的是检测MUC1和MUC2糖蛋白在喉癌中的表达,并确定mucin的表达是否与预后有关。本研究包括57例喉癌患者的喉部标本,其中36例为喉癌,21例为正常对照。MUC1在癌组和正常对照组中均有高表达(P = 0.689, Fisher精确检验)。与对照组相比,MUC2的高水平表达仅在癌中检测到(P = 0.009, Fisher精确检验)。通过多变量分析,MUC1和MUC2的表达与生存均无显著相关性。MUC1的表达与T期相关。T期晚期与预后相关(P = 0.001)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression of MUC1 and MUC2 glycoproteins in laryngeal cancer.
The aim of this study was to examine the expression of MUC1 and MUC2 glycoproteins in laryngeal cancer and to determine if mucin expression is related to prognosis. The study included laryngeal specimens from 57 patients comprising of 36 laryngeal carcinomas and 21 normal controls. High MUC1 expression was found in both carcinomas and normal control groups (P = 0.689, Fisher's exact test). High levels of MUC2 expression were only detected in carcinomas versus controls (P = 0.009, Fisher's exact test). Using multivariate analysis neither MUC1 nor MUC2 expression significantly related to survival. MUC1 expression however, did correlate with T stage. Advanced T stage was associated with prognosis (P = 0.001).
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