缺水大鼠和Brattleboro大鼠皮质下器官心房钠肽(6-33)结合位点增加。

J. Saavedra, A. Israel, F. Corrêa, M. Kurihara
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引用次数: 4

摘要

在慢性脱水、不能合成抗利尿素的纯合子Brattleboro大鼠皮下器官中定量测定了大鼠心房利钠肽(6-33)的结合位点;断水4 d后,将杂合子Brattleboro大鼠、对照组、Long Evans大鼠和Long Evans大鼠分别饲养。脑切片在125I-ANP存在下孵育,并通过放射自显影结合计算机微密度测量和与125i标准的比较分析结果。Brattleboro大鼠和缺水的Long Evans大鼠的ANP结合位点数量高于正常补水的对照组。我们的研究结果表明,皮质下器官中的ANP结合位点在液体平衡和抗利尿激素分泌的中枢调节中起着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increased atrial natriuretic peptide (6-33) binding sites in the subfornical organ of water deprived and Brattleboro rats.
Binding sites for rat atrial natriuretic peptide (6-33) (ANP) were quantitated in the subfornical organ of chronically dehydrated homozygous Brattleboro rats unable to synthesize vasopressin; heterozygous Brattleboro rats, their controls, Long Evans rats and Long Evans rats after 4 days of water deprivation. Brain sections were incubated in the presence of 125I-ANP and the results analyzed by autoradiography coupled to computerized microdensitometry and comparison to 125I-standards. Brattleboro rats and water deprived Long Evans rats presented a higher number of ANP binding sites than their normally hydrated controls. Our results suggest a role of ANP binding sites in the subfornical organ in the central regulation of fluid balance and vasopressin secretion.
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