Martha Sofía Vargas-Santana, Ana María Cruz-González, Néstor Enrique Cerquera, Alana Sofia Escobar Rodriguez, Rossember E. Cárdenas, Omar Calderón-Losada, C. Ortiz, D. R. Delgado
{"title":"扩展Hildebrand溶解度法和Yalkowsky-Roseman模型估计磺胺嘧啶和磺胺乙嘧啶在某些{乙二醇(1)+水(2)}混合物中的溶解度","authors":"Martha Sofía Vargas-Santana, Ana María Cruz-González, Néstor Enrique Cerquera, Alana Sofia Escobar Rodriguez, Rossember E. Cárdenas, Omar Calderón-Losada, C. Ortiz, D. R. Delgado","doi":"10.15446/rcciquifa.v50n3.100240","DOIUrl":null,"url":null,"abstract":"Aim: extended Hildebrand Solubility Approach (EHSA) and Yalkowsky Roseman (YR) were applied to evaluate the solubility of sulfadiazine, and sulfamethazine in ethylene glycol + water mixtures. Methodology: reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations.Results: a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order two correlating the inter-action parameter W with the Hildebrand solubility parameter of solvent mixtures without drug ; however, the results obtained from YR model show relatively high deviations greater than 50%.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"82 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures\",\"authors\":\"Martha Sofía Vargas-Santana, Ana María Cruz-González, Néstor Enrique Cerquera, Alana Sofia Escobar Rodriguez, Rossember E. Cárdenas, Omar Calderón-Losada, C. Ortiz, D. R. Delgado\",\"doi\":\"10.15446/rcciquifa.v50n3.100240\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: extended Hildebrand Solubility Approach (EHSA) and Yalkowsky Roseman (YR) were applied to evaluate the solubility of sulfadiazine, and sulfamethazine in ethylene glycol + water mixtures. Methodology: reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations.Results: a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order two correlating the inter-action parameter W with the Hildebrand solubility parameter of solvent mixtures without drug ; however, the results obtained from YR model show relatively high deviations greater than 50%.\",\"PeriodicalId\":21220,\"journal\":{\"name\":\"Revista Colombiana de Ciencias Químico-Farmacéuticas\",\"volume\":\"82 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-02-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Colombiana de Ciencias Químico-Farmacéuticas\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15446/rcciquifa.v50n3.100240\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Colombiana de Ciencias Químico-Farmacéuticas","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15446/rcciquifa.v50n3.100240","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures
Aim: extended Hildebrand Solubility Approach (EHSA) and Yalkowsky Roseman (YR) were applied to evaluate the solubility of sulfadiazine, and sulfamethazine in ethylene glycol + water mixtures. Methodology: reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations.Results: a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order two correlating the inter-action parameter W with the Hildebrand solubility parameter of solvent mixtures without drug ; however, the results obtained from YR model show relatively high deviations greater than 50%.
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