下面的皮肤提示:Vogt-Koyanagi-Harada病的白癜风

IF 2.3 4区 医学 Q2 DERMATOLOGY
Jong Ho Lim, Wooi-Chiang Tan, N. Nor
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引用次数: 0

摘要

Vogt-Koyanagi-Harada病(VKHD)是一种严重威胁视力的自身免疫性疾病。它的一个相关特征是白癜风。关于白癜风与VKHD疾病活动性之间关系的研究很少。作者从发病机制、临床表现、危险因素和疾病活动度等方面检索了VKHD患者白癜风与眼部疾病活动度关系的文献。其中一项发现是,早期治疗VKHD可能与完全康复有关。脊髓灰质炎和白癜风的逆转与葡萄膜炎的缓解有关,但反过来并不成立,因此白癜风的恶化可能不反映葡萄膜炎的恶化。免疫治疗与vogt - koyanagi - harada样疾病之间可能存在关联。总之,白癜风是一种免疫介导的皮肤表现,可能有助于VKHD的诊断和治疗策略。白癜风的遗传差异仍需要进一步研究,并可能有助于这种疾病的具体监测和治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hints from the skin beneath: Vitiligo in Vogt–Koyanagi–Harada disease
Vogt–Koyanagi–Harada disease (VKHD) is a major vision-threatening autoimmune disease. One of its associated features is vitiligo. Little study has been done on the association between vitiligo and the disease activity of VKHD. The authors searched available literature on the relationship between vitiligo and ophthalmic disease activity in VKHD in terms of pathogenesis, clinical presentations, risk factors as well as disease activity. Among the findings is that early treatment of VKHD may be associated with full recovery. The reversal of poliosis and vitiligo is associated with the remission of uveitis, but the reverse does not hold true, whereby the worsening of vitiligo may not reflect the worsening of uveitis. It is also found that there may be an association between immunotherapy and Vogt–Koyanagi–Harada-like disease. In summary, vitiligo is an immune-mediated cutaneous manifestation which may contribute to diagnostic and treatment strategies in VKHD. Future research on genetic differences in vitiligo is still needed and may contribute to specific monitoring and therapeutic approach in this disease.
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来源期刊
Dermatologica Sinica
Dermatologica Sinica DERMATOLOGY-
CiteScore
2.80
自引率
20.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating dermatological-related medical science knowledge to improve global health. Articles on clinical, laboratory, educational, and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, brief reports, case reports and correspondence are accepted.
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