含有1,2-唑片段的新型金刚乙胺和金刚烷酸衍生物的合成

Q4 Chemistry

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2023-09-04 DOI:10.29235/1561-8331-2023-59-3-211-224

E. A. Akishina, Е. А. Dikusar, P. Kurman, V. Potkin

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引用次数: 0

摘要

金刚乙胺与取代的羟基苯甲醛、酯类、醚类以及1,2-唑-3-乙醛缩合，然后还原得到各种金刚烷衍生物。具有活性氨基和羟基的衍生物的进一步酰化得到在一个分子中含有两个1,2-唑片段的化合物。

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Synthesis of novel rimantadine and adamantane-1-carboxylic acid derivatives with 1,2-azole fragments

Various adamantane derivatives were obtained by the condensation of rimantadine with substituted hydroxy-benzaldehydes, esters and ethers based on them, as well as 1,2-azole-3-carbaldehydes, followed by reduction. Further acylation of derivatives with active amino and hydroxy groups yielded compounds containing two 1,2-azole fragments in one molecule.

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来源期刊

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Chemistry-Chemistry (miscellaneous)

CiteScore

0.30

自引率

0.00%

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