Advanced platelet rich fibrin in periodontal regeneration

Regenerating periodontal tissue is the main goal of periodontal therapy. Periodontal tissue regeneration involves the development of new bone, cement, and periodontal ligaments on damaged tooth root surfaces in order to restore anatomy and function. In order to further enhance PRF (Platelet rich fibrin) and develop advanced platelet-rich fibrin, a slower rotating speed is proposed (A-PRFs). Cell dispersion is affected by centrifugation rate. The majority of the leukocytes in the PRF are concentrated near the bottom of the tube due to centrifugation rate. By switching the centrifugation process to 1,500 rpm for 14 minutes, granulocyte neutrophils and the fibrin matrix are more evenly distributed in the A-PRF created. Hence, a periodontal evaluation of this subject is required.