Toxicity of CaO Nanoparticles effect on Haematology and Histopathology of male Rabbits

Calcium oxide (CaO) nanoparticle (NP) was synthesized by a simple chemical method. The CaONPs were characterized by X-ray diffraction (XRD), Scanning Electron Microscope (SEM) analysis, and UV-absorption spectral studies. The average crystallite size was found to be ≈36nm and the band gap energy of the CaO nanoparticle was 1.9 eV. Toxicity tests were performed on adult rabbits dosed with compound CaONPs for a period of (3 weeks). Areas of necrosis, hemorrhages, and degenerations were seen histopathologically in the kidney, and liver after 3 weeks of administration of CaONPs, the data of hematology obtained was statistically evaluated using Finney’s Probit Analysis and the Toxicity test performed revealed that the Ld50 value was 0.5ml/kg. This study found that an increase in the proportion of calcium oxide in the blood leads to damage to the organs, like the liver and kidneys that are responsible for filtering the blood.