头孢菌素:药理学和化学

K. Shahbaz
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引用次数: 14

摘要

头孢菌素是最重要的具有β-内酰胺环的抗生素,从一种真菌Acremonium中提取,也称为头孢菌。头孢菌素广泛用于对抗各种严重感染的细菌,如呼吸道感染(RTI)、皮肤感染和尿路感染(UTI),这使得科学家们深入研究了这种抗菌药物的细节。了解头孢菌素的构效关系(SAR)、抑制谱(SOI)、化学性质和药理学对设备的先进治疗效果具有关键影响。使用头孢菌素治疗疾病有许多优点和缺点。如果正确了解这种药物的药理学和化学性质,许多副作用可以减少或最小化到一定程度。本文综述了头孢菌素的一些药理和化学性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cephalosporins: pharmacology and chemistry
Cephalosporins are the most important antibiotics having β-lactam ring and are obtained from a fungus Acremonium, also known as cephalosporium. The wide use of cephalosporins against bacteria in various severe infections such as respiratory tract infection (RTI), skin infection and urinary tract infection (UTI) has led the scientist dive into the detail of this antibacterial drug. The knowledge about structural activity relationship (SAR), spectrum of inhibition (SOI), chemical properties and pharmacology of cephalosporin has pivotal impact to device advanced therapeutic results. The treatment of a disease using cephalosporin has many pros and cons. If the pharmacology and chemical properties of this drug are known properly, many side effects can be diminished or minimized to a certain level. This article review some pharmacological and chemical properties of cephalosporins.
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