小鼠肺的定量形态学及其在肺部疾病研究中的重要性

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2019-06-01 DOI:10.1016/j.ddmod.2019.09.002

Wilfried Klein

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引用次数: 0

摘要

小鼠呼吸系统的形态学已经在几种不同的呼吸系统疾病模型中得到了研究，但定量形态学方法，如体视学，仍然只是零星地使用。这篇综述讨论了使用立体学作为工具来了解小鼠呼吸系统的形态及其与肺力学研究的联系。提出了一种综合研究小鼠肺功能的方法，通过结合非侵入性和侵入性方法来分析肺力学，结合肺形态学的立体学研究。

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Quantitative morphology of the lung and its importance in investigations of pulmonary diseases in mice

The morphology of the mouse respiratory system has been studied in several different models of respiratory diseases, but quantitative morphological methods such as stereology are still only employed sporadically. This review discusses the use of stereology as a tool to understand the morphology of the mouse respiratory system and its link to the study of pulmonary mechanics. An integrated approach to study lung function in mice is being proposed, by combining non-invasive and invasive methods to analyze pulmonary mechanics, coupled with stereological investigations of lung morphology.

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.