自身免疫性胃炎:一个被低估的实体

IF 0.2

AJSP-Reviews and Reports Pub Date : 2019-07-01 DOI:10.1097/PCR.0000000000000320

K. Matsukuma, M. Torbenson

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引用次数: 0

摘要

自身免疫性胃炎是一种相对常见但可能未被确诊的慢性胃炎，它与缺铁性贫血以及维生素B12/钴胺素缺乏症有关。由于胃泌素水平持续升高，本病发生胃高分化神经内分泌肿瘤的风险增加13倍，发生胃腺癌的风险增加3- 7倍。这里所描述的病例具有典型的疾病表现，下面的综述强调了有助于识别这种炎症过程的关键组织学特征。此外，对辅助检测和疾病机制的背景信息进行了讨论，重点讨论了对病理学家最有用的细节，病理学家有机会做出这种通常出乎意料但具有医学意义的诊断。

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Autoimmune Gastritis: An Underappreciated Entity

Autoimmune gastritis is a relatively common but likely underdiagnosed form of chronic gastritis that is associated with iron-deficiency anemia as well as vitamin B12/cobalamin deficiency. This disease confers a 13-fold increased risk of gastric well-differentiated neuroendocrine tumors, due to persistently elevated gastrin levels, and a 3- to 7-fold increased risk of gastric adenocarcinoma. The case described here has a typical presentation of the disease, and the following review highlights key histologic features that aid in the identification of this inflammatory process. Additionally, background information on ancillary testing and mechanisms of disease are discussed with a focus on details most useful for the pathologist who is presented with the opportunity to make this often unexpected but medically significant diagnosis.

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来源期刊

AJSP-Reviews and Reports PATHOLOGY-

自引率

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期刊介绍： Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.