光诱导移植物抗宿主病

J. Hardy, M. Marguery, A. Huynh, C. Borel, P. Apoil, L. Lamant, E. Tournier, Chloé Alberto, C. Pauwels, Marianne Thomas, J. Mazereeuw Hautier, C. Paul, C. Bulai Livideanu
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引用次数: 2

摘要

重叠慢性移植物抗宿主病(GVHD)与急性和慢性移植物抗宿主病的特征相关。慢性GVHD的触发因素尚不清楚。我们描述了两例接受同种异体造血干细胞移植的患者,他们后来在阳光照射后发展为重叠慢性GVHD。来自体内研究的现有数据表明,紫外线B辐射(UVB)对急性和慢性GVHD有有益的影响。太阳照射作为同构皮肤GVHD的触发因素的作用在文献中很少报道。在这里,我们首次证明,使用重复宽带光测试,UVB触发慢性GVHD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Photo‐induced graft‐versus‐host disease
Overlap chronic graft‐versus‐host disease (GVHD) associates both features of acute and chronic GVHD. Trigger factors for chronic GVHD are unclear. We describe two patients who received allogenic haematopoietic stem‐cell transplantation, and who later developed overlap chronic GVHD after sun exposure. Available data from in vivo investigations suggest ultraviolet B radiation (UVB) has a beneficial effect on acute and chronic GVHD. The role of sun irradiation as a trigger for isomorphic cutaneous GVHD has been rarely reported in the literature. Herein, we demonstrate for the first time, using repetitive broadband phototesting, that UVB triggers chronic GVHD.
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