Feni Istikharoh, H. Sujuti, E. Mustamsir, Astika Swastirani
{"title":"添加PLGA用于牙槽嵴保存的HANP/PVA复合材料膨胀行为研究","authors":"Feni Istikharoh, H. Sujuti, E. Mustamsir, Astika Swastirani","doi":"10.15562/jdmfs.v6i3.998","DOIUrl":null,"url":null,"abstract":"Objective: The aim of this study was to compare the swelling behaviour of HANP/PVA and HANP/PLGA/PVA composites. Material and Methods: This study was divided into 2 groups, HANP/ PVA and HANP/PLGA/PVA composites which prepared by freeze drying methods. HANP 20% (w/w) was combined with PLGA 20% (w/w) and dissolved in PVA solution at 50C. Swelling behaviour was obtained by measured initial weight (Wi) and the weight of composites after immersing in PBS pH 7.4; 37C for 7 days (Ws). Statistical analysis based on Independent T-test (p<0.05). Results: The initial weight (Wi) of HANP/PVA and HANP/PLGA/PVA composites are 467±4.73 and 292±9.52. The swollen weight (Ws) of HANP/PVA and HANP/PLGA/PVA composites are 897±26.61 and 860±32.36. Furthermore, the water retention of HANP/PVA composite is 92.07% (p<0.05) and HANP/PLGA/PVA composite is 194.52% (p<0.05). Conclusion: The addition of PLGA enhance swelling behaviour of HANP/PVA composites. The strong interaction between HANP and PVA decrease the swelling re. HANP is inert in nature, but the combination of HANP/PLGA/PVA can be a good substitute for alveolar preservation.","PeriodicalId":31119,"journal":{"name":"Journal of Dentomaxillofacial Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation\",\"authors\":\"Feni Istikharoh, H. Sujuti, E. Mustamsir, Astika Swastirani\",\"doi\":\"10.15562/jdmfs.v6i3.998\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: The aim of this study was to compare the swelling behaviour of HANP/PVA and HANP/PLGA/PVA composites. Material and Methods: This study was divided into 2 groups, HANP/ PVA and HANP/PLGA/PVA composites which prepared by freeze drying methods. HANP 20% (w/w) was combined with PLGA 20% (w/w) and dissolved in PVA solution at 50C. Swelling behaviour was obtained by measured initial weight (Wi) and the weight of composites after immersing in PBS pH 7.4; 37C for 7 days (Ws). Statistical analysis based on Independent T-test (p<0.05). Results: The initial weight (Wi) of HANP/PVA and HANP/PLGA/PVA composites are 467±4.73 and 292±9.52. The swollen weight (Ws) of HANP/PVA and HANP/PLGA/PVA composites are 897±26.61 and 860±32.36. Furthermore, the water retention of HANP/PVA composite is 92.07% (p<0.05) and HANP/PLGA/PVA composite is 194.52% (p<0.05). Conclusion: The addition of PLGA enhance swelling behaviour of HANP/PVA composites. The strong interaction between HANP and PVA decrease the swelling re. HANP is inert in nature, but the combination of HANP/PLGA/PVA can be a good substitute for alveolar preservation.\",\"PeriodicalId\":31119,\"journal\":{\"name\":\"Journal of Dentomaxillofacial Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Dentomaxillofacial Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15562/jdmfs.v6i3.998\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dentomaxillofacial Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15562/jdmfs.v6i3.998","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation
Objective: The aim of this study was to compare the swelling behaviour of HANP/PVA and HANP/PLGA/PVA composites. Material and Methods: This study was divided into 2 groups, HANP/ PVA and HANP/PLGA/PVA composites which prepared by freeze drying methods. HANP 20% (w/w) was combined with PLGA 20% (w/w) and dissolved in PVA solution at 50C. Swelling behaviour was obtained by measured initial weight (Wi) and the weight of composites after immersing in PBS pH 7.4; 37C for 7 days (Ws). Statistical analysis based on Independent T-test (p<0.05). Results: The initial weight (Wi) of HANP/PVA and HANP/PLGA/PVA composites are 467±4.73 and 292±9.52. The swollen weight (Ws) of HANP/PVA and HANP/PLGA/PVA composites are 897±26.61 and 860±32.36. Furthermore, the water retention of HANP/PVA composite is 92.07% (p<0.05) and HANP/PLGA/PVA composite is 194.52% (p<0.05). Conclusion: The addition of PLGA enhance swelling behaviour of HANP/PVA composites. The strong interaction between HANP and PVA decrease the swelling re. HANP is inert in nature, but the combination of HANP/PLGA/PVA can be a good substitute for alveolar preservation.
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