Application of Synthetic Peptides to Improve Parameters of Skin Physiology: An Open Observational 30-Day Study

We describe a novel, non-invasive peptide-based product intended to counter several pathophysiological signs of aged skin through the topical application of signalling molecule mimics. Several aesthetic parameters of skin physiology were assessed. The product was tested on 20 healthy Caucasian women (35 - 55 years-old) who applied the product twice-daily to the face for 30 days. Skin elasticity, firmness, sagging, brightness, and luminosity were assessed. Additionally, over a period of 3 hours, the hydrating effect of the product vs placebo vs non-treated skin was assessed. After 30 days, participants showed significant increases in skin elasticity (11.8% increase, p < 0.01), luminosity (2.5% increase, p < 0.01), and brightness (110% increase, p < 0.001) with concomitant significant decreases in skin sagging (6.3% decrease, p < 0.05). The product gave a rapid and sustained hydrating action that was significantly greater than placebo alone (10.2% increase, p < 0.05). No adverse reactions were reported. Cosmetic products based on the action of synthetic peptide mimics of endogenous signalling molecules show promise for combatting the pathological degradation of skin as seen in the elderly. Strategies to reverse these symptoms through non-invasive techniques warrant further investigation. This study provides support for the application of peptides to combat signs of aging and to improve the general condition of the skin.