{"title":"微粒径载体包埋增强阿托伐他汀溶解度的研究","authors":"Rédai Emőke, Zsombori Mónika, Székely-Szentmiklósi Blanka, Sipos Emese","doi":"10.2478/orvtudert-2019-0004","DOIUrl":null,"url":null,"abstract":"Abstract The aim of this experimental work was the enhancement of water solubility of the lipid lowering atorvastatin, by embedding it in polymer based micro sized fibers obtained by electrospinning. We prepared a polyvinylpyrrolidone (Kollidon 90F®) dispersion and added the active substance. By setting the experimental parameters we obtained four different microfibers containing atorvastatin, and one without the drug. The pH, viscosity and conductivity of the dispersions have been measured. The drug content and dissolution of atorvastatin had been studied by capillary electrophoresis. The size and thermal behavior of the fibers was determined. The parameters of the microfibers are influenced by the experimental parameters of electrospinning. The micro-method for dissolution showed a twofold solubility enhancement.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"51 1","pages":"47 - 52"},"PeriodicalIF":0.0000,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solubility enhancement of atorvastatin by embedding in micro sized carrier\",\"authors\":\"Rédai Emőke, Zsombori Mónika, Székely-Szentmiklósi Blanka, Sipos Emese\",\"doi\":\"10.2478/orvtudert-2019-0004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract The aim of this experimental work was the enhancement of water solubility of the lipid lowering atorvastatin, by embedding it in polymer based micro sized fibers obtained by electrospinning. We prepared a polyvinylpyrrolidone (Kollidon 90F®) dispersion and added the active substance. By setting the experimental parameters we obtained four different microfibers containing atorvastatin, and one without the drug. The pH, viscosity and conductivity of the dispersions have been measured. The drug content and dissolution of atorvastatin had been studied by capillary electrophoresis. The size and thermal behavior of the fibers was determined. The parameters of the microfibers are influenced by the experimental parameters of electrospinning. The micro-method for dissolution showed a twofold solubility enhancement.\",\"PeriodicalId\":9334,\"journal\":{\"name\":\"Bulletin of Medical Sciences\",\"volume\":\"51 1\",\"pages\":\"47 - 52\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Medical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/orvtudert-2019-0004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/orvtudert-2019-0004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Solubility enhancement of atorvastatin by embedding in micro sized carrier
Abstract The aim of this experimental work was the enhancement of water solubility of the lipid lowering atorvastatin, by embedding it in polymer based micro sized fibers obtained by electrospinning. We prepared a polyvinylpyrrolidone (Kollidon 90F®) dispersion and added the active substance. By setting the experimental parameters we obtained four different microfibers containing atorvastatin, and one without the drug. The pH, viscosity and conductivity of the dispersions have been measured. The drug content and dissolution of atorvastatin had been studied by capillary electrophoresis. The size and thermal behavior of the fibers was determined. The parameters of the microfibers are influenced by the experimental parameters of electrospinning. The micro-method for dissolution showed a twofold solubility enhancement.