重金属和砷沿“土壤-药用植物-水提取物”链跨介质过渡的特点

N. Dyakova
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引用次数: 3

摘要

劣质草本原料及其制品是各种生态毒物特别是重金属进入人体的重要来源。药用植物原料的水萃取——煎剂和输液——在这方面特别令人感兴趣,因为它们是医疗和制药实践以及传统医学中最容易获得和最常用的剂型,目前作为人体各种微量元素摄入来源的研究还不够充分。目的:探讨“土壤-药用植物原料-汤剂”链中重金属和砷的跨界过渡特征。材料和方法。原料在沃罗涅日生物圈保护区的花期采收。在ELAN-DRC装置上用质谱法研究了样品的微量元素组成。结果。沃罗涅日地区天然草本植物药用植物原料中有毒微量元素的含量不超过药典要求,其在总矿物质复合物中的总比例不超过0.011%。所研究原料所配制的汤剂和煎剂均符合药典对标准化元素含量的要求。药用植物浸剂和煎剂对镉、砷和铅的转移效率分别为9.02% ~ 55.00%、26.33% ~ 68.46%和1.95% ~ 76.15%。在“土壤-药用植物-水提取物”链条中,LRS中标准化元素最大程度地迁移到牛蒡根煎液中:镉- 74.91%,砷- 13.98%,铅- 6.02%。所研究的花中镉- 4.78%,砷- 0.46%,铅- 0.73%的转化程度最低。结论。这些发现具有极大的意义,可用于进一步的研究,并可用于医疗和制药实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peculiarities of heavy metal and arsenic trans-medium transition along the chain "soil - medicinal plant material - water etracts"
Low-quality herbal raw materials and the products obtained from them are important sources of various ecotoxicants, especially heavy metals, entering the human body. Aqueous extractions of medicinal plant raw materials - decoctions and infusions - are of a particular interest in this respect - as they are the most accessible and frequently used dosage forms in medical and pharmaceutical practice and traditional medicine, being at present insufficiently studied as sources of intake of various microelements in the human body. Objective: to investigate the peculiarities of heavy metals and arsenic trans-mediated transition along the chain "soil - medicinal plant raw materials - infusions and decoctions". Materials and methods. Raw materials were harvested during the flowering period in Voronezh Biosphere Reserve. The microelement composition of the samples was studied by mass spectroscopy on an ELAN-DRC device. Results. The content of toxic microelements estimated in medicinal plant raw materials of natural phytocenosis of Voronezh region does not exceed the pharmacopoeial requirements, and their total proportion in the total mineral complex - not more than 0.011%. All made infusions and decoctions from the studied raw materials infusions and decoctions also corresponded to pharmacopoeial requirements on the content of normalized elements. The efficiency of cadmium transfer in infusions and decoctions from medicinal plant raw materials ranged from 9.02% to 55.00%, arsenic - from 26.33% to 68.46%, lead - from 1.95% to 76.15%. In the chain "soil - medicinal plant material - water extracts" normalized elements in LRS to the greatest extent migrated to the decoction of burdock root: cadmium - 74.91%, arsenic - 13.98%, lead - 6.02%. The lowest degree of transition was noted for the infusion of the studied flowers: for cadmium - 4.78%, arsenic - 0.46%, lead - 0.73%. Conclusion. The findings are of great interest and may serve both for further research and for using in medical and pharmaceutical practice.
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