Prutha Joshi, Md Shakir Uddin Ahmed, K. Vig, M. Auad
{"title":"具有类似生物组织的物理化学性质的生物医学应用的聚合物双网络(DNs)的配方","authors":"Prutha Joshi, Md Shakir Uddin Ahmed, K. Vig, M. Auad","doi":"10.3390/suschem3020016","DOIUrl":null,"url":null,"abstract":"Single-network hydrogels can have an internal porous structure and biocompatibility, but have lower mechanical properties. Combining these properties with another biocompatible and mechanically strong network can help in mimicking the extracellular matrix of native tissues to make them suitable for tissue scaffolds with desired performance. In the current objective, we combine the properties of poly (ethylene glycol) dimethacrylate (PEGDMA) macromer and polysaccharides as the two components in double networks (DN) for synergistic effects of both components resulting in the interpenetrating polymeric network for making it functional for replacement of injured tissues. The hydrogels were characterized by physical properties like swelling ratio, mechanical properties like tensile and compressive modulus, and rheological behavior. The chemical composition was studied using Fourier transform infrared spectroscopy (FTIR), and the thermal behavior using differential scanning calorimetry (DSC) experiments. Biodegradability and mechanical strength both are gained using double networks (DN), thus making it resemble more like living tissues. DN hydrogels were tested for cell compatibility for possible application in tissue engineering. Furthermore, these properties may allow their application as tissue-engineered scaffolds.","PeriodicalId":22103,"journal":{"name":"Sustainable Chemistry","volume":"25 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Formulation of the Polymeric Double Networks (DNs) for Biomedical Applications with Physicochemical Properties to Resemble a Biological Tissue\",\"authors\":\"Prutha Joshi, Md Shakir Uddin Ahmed, K. Vig, M. Auad\",\"doi\":\"10.3390/suschem3020016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Single-network hydrogels can have an internal porous structure and biocompatibility, but have lower mechanical properties. Combining these properties with another biocompatible and mechanically strong network can help in mimicking the extracellular matrix of native tissues to make them suitable for tissue scaffolds with desired performance. In the current objective, we combine the properties of poly (ethylene glycol) dimethacrylate (PEGDMA) macromer and polysaccharides as the two components in double networks (DN) for synergistic effects of both components resulting in the interpenetrating polymeric network for making it functional for replacement of injured tissues. The hydrogels were characterized by physical properties like swelling ratio, mechanical properties like tensile and compressive modulus, and rheological behavior. The chemical composition was studied using Fourier transform infrared spectroscopy (FTIR), and the thermal behavior using differential scanning calorimetry (DSC) experiments. Biodegradability and mechanical strength both are gained using double networks (DN), thus making it resemble more like living tissues. DN hydrogels were tested for cell compatibility for possible application in tissue engineering. Furthermore, these properties may allow their application as tissue-engineered scaffolds.\",\"PeriodicalId\":22103,\"journal\":{\"name\":\"Sustainable Chemistry\",\"volume\":\"25 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sustainable Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/suschem3020016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sustainable Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/suschem3020016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Formulation of the Polymeric Double Networks (DNs) for Biomedical Applications with Physicochemical Properties to Resemble a Biological Tissue
Single-network hydrogels can have an internal porous structure and biocompatibility, but have lower mechanical properties. Combining these properties with another biocompatible and mechanically strong network can help in mimicking the extracellular matrix of native tissues to make them suitable for tissue scaffolds with desired performance. In the current objective, we combine the properties of poly (ethylene glycol) dimethacrylate (PEGDMA) macromer and polysaccharides as the two components in double networks (DN) for synergistic effects of both components resulting in the interpenetrating polymeric network for making it functional for replacement of injured tissues. The hydrogels were characterized by physical properties like swelling ratio, mechanical properties like tensile and compressive modulus, and rheological behavior. The chemical composition was studied using Fourier transform infrared spectroscopy (FTIR), and the thermal behavior using differential scanning calorimetry (DSC) experiments. Biodegradability and mechanical strength both are gained using double networks (DN), thus making it resemble more like living tissues. DN hydrogels were tested for cell compatibility for possible application in tissue engineering. Furthermore, these properties may allow their application as tissue-engineered scaffolds.