DOXYCYCLINE EFFICIENCY AND SAFETY IN THE TREATMENT OF ACUTE INTESTINAL INFECTIONS OF BACTERIAL ETIOLOGY IN BROILER CHICKENS

Doxycycline is a bacteriostatic antibiotic from the group of tetracyclines, a semi-synthetic derivative of chloretracycline. It is a broad-spectrum antibiotic that is active in gram- positive and gram- negative bacteria, including some anaerobes. Therefore, the use of doxycycline drugs is relevant to solve the problem of treatment and control of mono- and polyinfections, which are caused by doxycycline sensitive and other antibiotics resistant to other antibiotics. The article presents the results of clinical studies of a new veterinary drug Doxal (water-soluble powder for oral administration), production of PJSC “Technologist” (Ukraine), an active pharmaceutical ingredient of which is doxycycline, in the treatment of acute intestinal disease in broiler chickens. A high level of therapeutic efficacy and safety of the Doxal studied drug in the treatment of chickens 25 daily age with colibacteriose-claspidiosis infection was established. The diagnosis was made on the basis of anamnestic data, a clinical picture of the disease, the results of pathoanatomical section and bacteriological examination. Microorganisms – pathogens of infection, their level of sensitivity to doxycycline were selected and identified. Therapeutic efficiency of the tested drug was not inferior to the drug-comparison of Doxatib®, production of KRKA DD Novo-Mesto (Slovenia), similar in dosage form and the content of the active substance. According to the results of laboratory tests, a positive effect of Doxal on the morpho-functional state of the body of chickens in the treatment of acute colibacteriosis-claspidiosis infection was revealed, which is confirmed by normalization with a high percentage of the reliability of morphological and biochemical blood indicators to the values of clinically healthy bird. Comparative clinical studies have confirmed that Doxal drug is effective chemotherapeutic agent for the treatment of bacterial infections in chickens caused by microorganisms sensitive to doxycycline, and is analogous to Doxatib® by it’s action.