超声辅助高效合成 1-苯基咪唑并[1,5-a]吡啶的偶氮甲基衍生物

IF 2.4 3区化学 Q2 CHEMISTRY, ORGANIC

Polycyclic Aromatic Compounds Pub Date : 2024-02-07 DOI:10.1080/10406638.2023.2180527

Suhas G. Patil , Jagannath S. Jadhav , Hemant V. Chavan , Sagar T. Sankpal

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引用次数: 0

摘要

在本研究工作中，实现了一系列 1-苯基咪唑并[1,5-a]吡啶的新型偶氮甲胺衍生物的超声辅助合成。合成路线包括将 1-苯基咪唑并[1,5-a]吡啶-3-羧酸乙酯转化为 1-苯基咪唑并[1,5-a]吡啶-3-羧酰肼，然后与多种芳香醛发生亲核加成-消除反应。所开发的简洁方案具有一系列优点，如反应条件温和、对环境友好、原子经济性高，而且收率极高（70-92%）。研究发现，所有化合物在大气条件下都能长期保持稳定，并可溶于极性溶剂。

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Ultrasound-Assisted Efficient Synthesis of Azomethine Derivatives of 1-Phenylimidazo[1,5-a]Pyridine

In the present research work, ultrasound-assisted synthesis of a series of novel azomethine derivatives of 1-phenylimidazo[1,5-a]pyridine has been achieved. The synthetic route involves the conversion of ethyl-1-phenylimidazo-[1,5-a]pyridine-3-carboxylate to 1-phenylimidazo[1,5-a]pyridine-3-carbohydrazide followed by nucleophilic addition-elimination reaction with diverse aromatic aldehydes. The developed clean and simple protocol offers a set of advantages such as mild reaction conditions, environment friendliness, and high atom economy apart from excellent yields (70–92%). All compounds were found to be stable in atmospheric conditions for a long period of time and were soluble in polar solvents.

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来源期刊

Polycyclic Aromatic Compounds 化学-有机化学

CiteScore

3.70

自引率

20.80%

发文量

412

审稿时长

3 months

期刊介绍： The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.