快速冷却结晶过程中α和β dl -蛋氨酸的多态性控制

IF 1.5 4区材料科学 Q3 CRYSTALLOGRAPHY

Crystal Research and Technology Pub Date : 2021-03-24 DOI:10.1002/crat.202000208

M. Suresh, K. Srinivasan

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引用次数: 3

摘要

在323 ~ 274k的温度范围内，通过快速的冷却结晶过程，在饱和水溶液中产生了大范围的过饱和度(0.02 < σ < 2.19)，实现了必需氨基酸蛋氨酸α和β多晶的多晶控制和结晶成核。成核类型很大程度上依赖于过饱和:较低的过饱和范围(0.02 < σ < 0.08)倾向于稳定的β形式，较高的过饱和范围(1.20 < σ < 2.19)产生亚稳态α形式。原位光学显微镜和X射线衍射分析证实了生长的多晶的形态和结构差异。

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Polymorphic Control of α and β dl‐Methionine through Swift Cooling Crystallization Process

Polymorphic control and crystal nucleation of α and β polymorphs of dl‐methionine, an essential amino‐acid, is attained from saturated aqueous solution through swift cooling crystallization process by generating wide range of supersaturation (0.02 < σ < 2.19) in the temperature range of 323–274 K. The type of nucleation is very much supersaturation dependent: while lower supersaturation range (0.02 < σ < 0.08) prefers the stable β form, higher supersaturation range (1.20 < σ < 2.19) yields metastable α form. In situ optical microscopy and X‐ray diffraction analyses confirm the morphological and structural distinction of the grown polymorphs.

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来源期刊

Crystal Research and Technology 化学-晶体学

自引率

6.70%

发文量

121

审稿时长

1.9 months

期刊介绍： The journal Crystal Research and Technology is a pure online Journal (since 2012). Crystal Research and Technology is an international journal examining all aspects of research within experimental, industrial, and theoretical crystallography. The journal covers the relevant aspects of -crystal growth techniques and phenomena (including bulk growth, thin films) -modern crystalline materials (e.g. smart materials, nanocrystals, quasicrystals, liquid crystals) -industrial crystallisation -application of crystals in materials science, electronics, data storage, and optics -experimental, simulation and theoretical studies of the structural properties of crystals -crystallographic computing