{"title":"5,5 -二甲基-1-吡咯啉- n -氧化物对果蝇x射线遗传毒性的抑制作用","authors":"Y. Kimura, K. Kawai, K. Fujikawa, H. Furukawa","doi":"10.1248/JHS1956.44.233","DOIUrl":null,"url":null,"abstract":"The oxy-radical scavenger, 5, 5-dimethyl-1-pyrroline-N-oxide (DMPO), reduced the X-ray-induced mutant spot frequency. The inhibitory effect may be due to the scavenging of oxy-radicals in vivo by DMPO.","PeriodicalId":14851,"journal":{"name":"Japanese journal of toxicology and environmental health","volume":"22 1","pages":"233-235"},"PeriodicalIF":0.0000,"publicationDate":"1998-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inhibitory Effect of 5, 5-Dimethyl-1-pyrroline-N-oxide on Genotoxicity of X-rays in Drosophila\",\"authors\":\"Y. Kimura, K. Kawai, K. Fujikawa, H. Furukawa\",\"doi\":\"10.1248/JHS1956.44.233\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The oxy-radical scavenger, 5, 5-dimethyl-1-pyrroline-N-oxide (DMPO), reduced the X-ray-induced mutant spot frequency. The inhibitory effect may be due to the scavenging of oxy-radicals in vivo by DMPO.\",\"PeriodicalId\":14851,\"journal\":{\"name\":\"Japanese journal of toxicology and environmental health\",\"volume\":\"22 1\",\"pages\":\"233-235\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese journal of toxicology and environmental health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1248/JHS1956.44.233\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese journal of toxicology and environmental health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1248/JHS1956.44.233","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
氧自由基清除剂5,5 -二甲基-1-吡咯啉- n -氧化物(DMPO)降低了x射线诱导突变体的光斑频率。这种抑制作用可能是由于DMPO清除体内的氧自由基。
Inhibitory Effect of 5, 5-Dimethyl-1-pyrroline-N-oxide on Genotoxicity of X-rays in Drosophila
The oxy-radical scavenger, 5, 5-dimethyl-1-pyrroline-N-oxide (DMPO), reduced the X-ray-induced mutant spot frequency. The inhibitory effect may be due to the scavenging of oxy-radicals in vivo by DMPO.
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