Synthesis of beta-Tricalciumphosphate Powder through Aqueous Precipitation Method

Zhao Bin Xing Geng Yan / the General Hospital of Chinese People’s Armed Police Forces Department of orthopedics 69, yongding Road, Haidian district, Beijing 100039, China. Abstract—In the present study, we investigated the synthesis conditions and the cytocompatibility of single phase -tricalciumphosphate ( -TCP) powder in order to find a very strict regulation of synthesis parameters. The precursors through aqueous precipitation methods were synthesized under several different conditions like reaction pH (3.5~9) and temperature (23~80 ) and flowing nitrogen or not and Ca/P ratio (=1.41 or 1.50) of initial reagents. Eight groups of the powders were obtained after the precursor being sintered at 1100 and characterized by X-ray diffraction and four groups of single phase -TCP powders were studied in cytotoxicity assay. The experimental data indicate that single phase and cytocompatible -TCP powder can be obtained under the reaction condition with the low pH values (pH=4~7), high temperature (50~70 ), flowing nitrogen and strict Ca/P ratio of initial reagents (Ca/P=1.50).