天然化合物作为血红素加氧酶-1诱导剂以减少SARS-CoV-2感染后的有害后果

Current Chemical Biology Pub Date : 2021-10-11 DOI:10.2174/2212796815666211011142101

V. Sorrenti, Valeria Consoli, Salvo Grosso S., L. Vanella

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引用次数: 0

摘要

SARS-CoV-2病毒(严重急性呼吸综合征冠状病毒2)引起COVID - 19(冠状病毒病19)，这是一种全球大流行，导致多器官衰竭，发病率和死亡率高。有些人比其他人更脆弱，并在covid- 19之后产生有害后果。血红素加氧酶-1 (HO-1)的减少和游离血红素可能与COVID-19患者中观察到的许多炎症现象有关。因此，HO-1诱导剂可能被证明是COVID - 19的潜在治疗或预防剂。水果和蔬菜中存在的许多天然化合物，如多酚，都能诱发HO-1。本综述的目的是关注含有能够诱导HO-1的生物活性化合物的主要食品，以便明智地选择用于抵消SARS-CoV-2感染损害的食品。

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Natural compounds as heme oxygenase-1 inducers to reduce the deleterious consequences following SARS-CoV-2 infection

The virus SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) causes COVID 19 (COronaVIrus Disease 19), a global pandemic with multi-organ failure and resulting in high morbidity and mortality. Some individuals are more vulnerable than others and have deleterious consequences following covid- 19. It has been postulated that Heme oxygenase-1 (HO-1) reduction and free heme may contribute to many of the inflammatory phenomena observed in COVID-19 patients. Therefore, HO-1 inducers could prove to be potential therapeutic or preventive agents for COVID 19. Many of the natural compounds present in fruits and vegetables, such as polyphenols, resulted able to induce HO-1. Aim of this review is to focus on the main foods containing bioactive compounds able to induce HO-1 for an informed choice of foods to use to counteract damage from SARS-CoV-2 infection.

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来源期刊

Current Chemical Biology Medicine-Biochemistry (medical)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems. Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc.; Asymmetric synthesis; Combinatorial synthesis; Diversity-oriented synthesis; Template-directed synthesis; Biomimetic synthesis; Solid phase biomolecular synthesis; Synthesis of small biomolecules: amino acids, peptides, lipids, carbohydrates and nucleosides; and Natural product synthesis).