T. Garibova, Таисия Леоновна Гарибова, T. Gudasheva, Татьяна Александровна Гудашева, S. Seredenin, Сергей Борисович Середенин
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The novel element in the mechanism of endogenous regulation of depressive-like states
It was shown previously that cyclo-prolylglycine, an endogenous neuropeptide, is a positive AMPA receptor modulator and is able to increase the content of BDNF in neurons. In the present work it was shown that cyclo-prolylglycine at a dose of 1 mg/kg with subchronic intraperitoneal administration reduces the time of animal immobility to passive control, from 167.6 to 83.6 s on the 12th day of the experiment using the model of learned helplessness in rats. That indicates the presence of antidepressant-like activity. The results of the study allow us to consider that cyclo-prolylglycine is a link in the physiological regulation of a depressive-like state.
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