探讨采用含乙醇湿巾采血测定酒精浓度的效果

T. Nakao, Atsushi Nitta, H. Nishioka, M. Katagi, Noriko Tsuda, Yasuhide Kitazawa
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引用次数: 0

摘要

本研究旨在确定使用含乙醇皮肤防腐剂的皮肤制剂是否会通过采血引起乙醇污染。根据国家采血指南采集40名健康志愿者静脉血,按以下4个步骤依次进行:1)使用单独包装的含乙醇擦拭器清洁皮肤后立即(5秒内)采集血液,2)使用单独包装的含乙醇擦拭器清洁皮肤1分钟后立即采集血液,3)使用传统清洁方法(彻底浸渍乙醇擦拭)清洁皮肤后立即(5秒内)采集血液,4)使用传统清洁方法清洁皮肤1分钟后采集血液。每个顺序的程序分别使用和不使用含乙醇的擦拭剂进行,该擦拭剂用于在拔针时清洁右手臂和左臂穿刺部位的皮肤。收集的样品采用顶空气相色谱-质谱法测定乙醇含量。从40名参与者中获得的每80份血液标本中,未检测到乙醇(<0.001 mg/mL)。本研究表明,根据采血指南,无论采用何种皮肤制备技术,使用含乙醇的皮肤防腐剂进行消毒都不太可能通过采血造成乙醇污染。这可能会对法医学产生影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
To Investigate the Effect of Using Ethanol Containing Wipes in Collecting Blood for the Measurement of Alcohol Concentration
This study was aimed to establish whether the skin preparation using ethanol-containing skin antiseptics causes ethanol contamination through blood collection. Venous blood was collected from 40 healthy volunteers according to the national guidelines for blood sampling, with four sequential procedures as follows: 1) collecting blood immediately (within 5 seconds) after cleaning the skin with an individually packaged type of ethanol-containing wipe, 2) collecting blood 1 minute after cleaning the skin with an individually packaged type of ethanol-containing wipe, 3) collecting immediately (within 5 seconds) after cleaning the skin with a traditional cleaning method (thoroughly ethanol-impregnated wipe, and 4) collecting 1 minute after cleaning the skin with a traditional cleaning method. Each sequential procedure was performed with and without the ethanol-containing wipe used for skin cleaning on the puncture site on their right and left arms at the time the needle was withdrawn, respectively. The collected specimens were subjected to the determination of ethanol by using headspace gas chromatography-mass spectrometry. In every 80 blood specimens obtained from 40 participants, ethanol was undetectable (<0.001 mg/mL). This study demonstrates that disinfection using ethanol-containing skin antiseptics is unlikely to cause ethanol contamination through blood collection regardless of skin preparation technique according to the guidelines for blood sampling. This may have implications in forensic science.
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