The Prognostic Value of Preoperative Neutrophil to Lymphocyte Ratio in the Penile Cancer: Meta Analysis

Objection: To evaluate the preoperative neutrophil to lymphocyte ratio in the prognosis of penile cancer. Methods: From the establishment of the database to January 2021, search for the Cochrane Library, PubMed, EMbase, CNKI, Wanfang database, papers that meet the inclusion and exclusion criteria will be obtained for meta analysis using RevMan 5.1 software and STATA 15.0 software. Results: Include 7 studies with 812 patients. The overall survival rate (HR=2.83 95% CI: 1.96-4.08, P<0.001) and progression-free survival rate (HR=1.62 95% CI: 1.17-2.23, P=0.004) of patients with preoperative high NLR was low; the overall survival of patients with positive lymph node metastasis (HR=4.13 95% CI: 2.47-6.90), P<0.001), progression-free survival (HR=3.88 95% CI: 2.15-5.32, P<0.001) is low; lymph node metastasis rate in patients with low NLR (OR=6.99 95%CI: 3.69-13.24, P<0.001) lower. Conclusions: Preoperative high NLR predicts a shorter overall survival rate and progression-free survival rate in patients with penile cancer. It can be considered that NLR is a simple and effective preoperative inflammatory index for predicting the prognosis of patients with penile cancer. It may provide a new perspective and help for clinical work, which will be good news for patients with penile cancer and clinicians.