手术矫治不畅的方法——600例手术经验

Martynov Vladimir Leonidovich
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引用次数: 0

摘要

大多数人都有反流回盲区神经支配的感觉神经元占主导地位,表明回盲瓣是人类肠道的一个高度敏感的结构。根据LG Peretz[1975]的研究,1ml的小肠含有多达5000个微生物,1g的大肠内容物含有约300 - 400亿个微生物。随着紫荆花瓣膜屏障功能的丧失,来自其他栖息地的外来微生物在小肠定植,发生生态失调1和某些病理后果对反流性肠炎患者粪便中酶含量的研究显示存在高发酵症,即肠激酶、碱性磷酸酶以及胆汁酸、胰腺酶和胃酶的含量增加。这种粪便高发酵症是肠道酶不完全失活,原胆汁酸解结的结果。粪性高发酵症,以及大肠(尤其是左半部分)中原发性胆汁酸的存在,是痉挛性结肠炎(尤其是左侧)的诱因M. Brotman[348]发现,在正常情况下,约95%的胆汁酸在回肠被吸收,然后重新进入肝脏,GG Nemsadze & EP Rybin4在192例结肠癌患者中发现,紫荆瓣膜功能衰竭后,胆汁酸的排泄量明显高于其正常功能。通过分析胆汁酸在肠肝循环中的代谢特点,获得了NBZ可能增加胆汁酸排泄的间接数据一些作者认为,通过胆汁酸形成致癌物质,类细菌可能会增加结肠癌的发病率其他作者则肯定地认为,“消除NBZ和使用抗反流吻合器,为手术预防癌前病变和结肠癌开辟了可能性。”
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of the method of surgical correction of insolvency bauginia damper-Experience of 600 operations
reflux in most people. The predominance of sensory neurons in the innervation of the ileocecal region indicates that the ileocecal valve is a highly sensitive formation of the human intestine. According to LG Peretz [1975], 1ml of the small intestine contains up to 5000 microbes, and 1g of the contents of the large intestine contains about 30-40 billion. With the loss of the barrier function of the Bauhinia valve, colonization of the small intestine by foreign microbes from another habitat occurs with the development of dysbiosis1 and certain pathological consequences.2 The study of the content of enzymes in the feces of patients with reflux enteritis showed the presence of hyperfermentosis, i.e., an increased content of enterokinase, alkaline phosphatase, as well as bile acids, pancreatic enzymes, and stomach enzymes. This fecal hyperfermentosis is a consequence of incomplete deactivation of intestinal enzymes, deconjugation of primary bile acids. Fecal hyperfermentosis, as well as the presence of primary bile acids in the large intestine, especially in its left half, serves as a trigger for spastic colitis, especially left-sided.3 M. Brotman [348] found that about 95% of bile acids are normally absorbed in the ileum, which re-enter the liver, GG Nemsadze & EP Rybin4 found in a group of 192 patients with colon cancer a significant increase in the excretion of bile acids with the failure of the Bauhinia valve in comparison with its normal function. Indirect data on the possible role of NBZ in increasing the excretion of bile acids were obtained by analyzing the characteristics of the metabolism of bile acids in the enterohepatic cycle.5 Some authors suggest that, through the formation of carcinogenic substances from bile acids, bacteroids may contribute to an increased incidence of colon cancer.6 Other authors7 definitely believe that “the elimination of NBZ and the use of anti reflux anastomosis open up the possibility of surgical prevention of precancerous diseases and colonic cancer.
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