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引用次数: 4
摘要
在最近的研究中(Libgot-Calle et al.， Ultras。地中海,杂志。，2007年出版)我们表明，同时测量高频声学参数可以提供有关体外人全血凝固的定量信息。高频声学参数以双透射(DT)和后向散射(BS)模式测量，并与凝血中的生物物理和生化变化有关。本研究的目的是区分红细胞(RBC)和血浆蛋白(特别是纤维蛋白网络的形成)对DT参数演变的各自影响，从而对凝块的机械特性产生影响。用30 MHz超声换能器测量全血、不同红细胞比容的血液、血浆和添加凝血酶的血浆中的声速和综合衰减系数(IAC)，结果表明红细胞对我们的参数有重要影响。
10C-2 High Frequency Ultrasound Characterization of Blood Clotting Process: Results Obtained With Plasma and Whole Blood
In recent studies (Libgot-Calle et al. , Ultras. Med. Biol. ,2007, in press) we showed that a simultaneous measurement of high frequency acoustic parameters could provide quantitative informations regarding the coagulation of human whole blood in vitro. HF acoustic parameters were measured both in double transmission (DT) and backscattering (BS) modes and were linked to biophysical and biochemical changes in clotting blood. The aim of this study was to discriminate the respective influence of red blood cells (RBC) and plasma proteins - especially fibrin network formation - on the evolution of our DT parameters and therefore on the mechanical properties of the clot. A 30 MHz ultrasonic transducer was used to estimate acoustic velocity and integrated attenuation coefficient (IAC) in whole blood, blood with various hematocrit, plasma, and plasma with added thrombin and the results underlined a major influence of RBC on our parameters.
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