在抗逆转录病毒治疗的背景下,hiv相关的心血管病理方面

M. Nagibina
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摘要

注释。由于科学医学文献中关于这种感染对心血管系统的负面影响的现有数据,确定不同阶段HIV感染患者的心脏病理学是相关的。这篇发表的文章介绍了60名艾滋病病毒感染第三阶段(20名患者)和第四阶段(40名患者)的心脏病检查结果。在22名(37%)艾滋病毒感染者中检测到心脏病理学,其中5名为3期,17名为4期。感染性心内膜炎合并三尖瓣病变在20例(91%)患者中比其他类型的心脏病理更常被诊断。与使用抗逆转录病毒疗法(ART)获得的结果比较表明,在整个疾病期间未接受抗逆转录病毒疗法的患者中,68.4%的病例检测到病理;在开始抗逆转录病毒治疗较晚或缺乏依从性的患者中,58%的病例检测到抗逆转录病毒;在及时、定期接受ART治疗的患者中,发现心脏疾病的几率为11.8%,是前者的5倍。这表明ART对HIV感染的心血管病理发展具有显著的抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ASPECTS OF HIV-ASSOCIATED CARDIOVASCULAR PATHOLOGY AGAINST THE BACKGROUND OF ANTIRETROVIRAL THERAPY
Annotation. The identification of cardiological pathology in patients at various stages of HIV infection is relevant due to the data available in the scientific medical literature on the negative impact of this infection on the cardiovascular system. The published article presents the results of a cardiological examination of 60 patients in the third (20 patients) and fourth (40 patients) stages of HIV infection. Cardiological pathology was detected in 22 (37%) HIV infected patients, 5 of them with stage 3 and 17 with stage 4 of the disease. Infectious endocarditis with tricuspid valve lesion was diagnosed more often than other types of cardiological pathology in 20 patients (91%). Comparison of the results obtained with the use of antiretroviral therapy (ART) showed that among patients who did not receive ART for the entire period of the disease, pathology was detected in 68.4% of cases; among patients with late initiation of ART or lack of adherence, it was detected in 58% of cases; in those who received ART in a timely and regular manner, cardiological pathology was found in five times less often in 11.8%. This suggests that ART has a significant inhibitory effect on the development of cardiovascular pathology in HIV infection.
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