Pasqua Dipasquale , Adele Romano , Silvia Cianci, Laura Righetti, Silvana Gaetani
{"title":"油基乙醇酰胺:能量代谢控制的新角色。在食物摄入中的作用","authors":"Pasqua Dipasquale , Adele Romano , Silvia Cianci, Laura Righetti, Silvana Gaetani","doi":"10.1016/j.ddmec.2011.01.004","DOIUrl":null,"url":null,"abstract":"<div><p>Oleoylethanolamide<span> (OEA) is a lipid amide produced by enterocytes upon the absorption of dietary fat and participates in the induction of satiety. Through indirect pathways, probably depending on the local activation of peroxisome-proliferator-activated receptor-alpha and involving afferent vagus nerve fibers, OEA signal is transmitted to the brain-stem and the hypothalamus, where it stimulates the release of oxytocin from magnocellular neurons.</span></p><p>OEA mechanism might, thus, provide a novel target for the design of therapies controlling appetite.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 3","pages":"Pages e169-e174"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.01.004","citationCount":"16","resultStr":"{\"title\":\"Oleoylethanolamide: a new player in energy metabolism control. Role in food intake\",\"authors\":\"Pasqua Dipasquale , Adele Romano , Silvia Cianci, Laura Righetti, Silvana Gaetani\",\"doi\":\"10.1016/j.ddmec.2011.01.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Oleoylethanolamide<span> (OEA) is a lipid amide produced by enterocytes upon the absorption of dietary fat and participates in the induction of satiety. Through indirect pathways, probably depending on the local activation of peroxisome-proliferator-activated receptor-alpha and involving afferent vagus nerve fibers, OEA signal is transmitted to the brain-stem and the hypothalamus, where it stimulates the release of oxytocin from magnocellular neurons.</span></p><p>OEA mechanism might, thus, provide a novel target for the design of therapies controlling appetite.</p></div>\",\"PeriodicalId\":72843,\"journal\":{\"name\":\"Drug discovery today. Disease mechanisms\",\"volume\":\"7 3\",\"pages\":\"Pages e169-e174\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.01.004\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug discovery today. Disease mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740676511000058\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676511000058","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Oleoylethanolamide: a new player in energy metabolism control. Role in food intake
Oleoylethanolamide (OEA) is a lipid amide produced by enterocytes upon the absorption of dietary fat and participates in the induction of satiety. Through indirect pathways, probably depending on the local activation of peroxisome-proliferator-activated receptor-alpha and involving afferent vagus nerve fibers, OEA signal is transmitted to the brain-stem and the hypothalamus, where it stimulates the release of oxytocin from magnocellular neurons.
OEA mechanism might, thus, provide a novel target for the design of therapies controlling appetite.
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