钩端螺旋体分泌金属蛋白酶天然免疫原性b细胞表位的鉴定:钩端螺旋体病多表位疫苗的新靶点

Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI:10.35259/isi.2022_52271

Fernanda Maia, Laura Ataídes, F. Conte, Rodrigo Silva

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摘要

以及毒力相关蛋白。这些蛋白表现为LIC13321-E1;LIC13321-E2)和4个(LIC10715-E1、LIC10715-E2、LIC10715-E3、LIC10715-E4)预测b细胞线性表位。对于预测表位的天然免疫原性，约8%的LG和25%的LG分别有针对LIC13321-E1和LIC13321-E2的抗体。此外，虽然只有6%的LG患者出现了针对LIC10715- e2的抗体，但超过25%的研究个体特异性识别了其他LIC10715表位。结论:在热溶钩端螺旋体中鉴定出4个天然免疫原性b细胞表位，并对其保护潜力进行评价，以进一步构建新型多表位疫苗。

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Identification of naturally immunogenic B-cell epitopes in Leptospira secreted metalloproteases: novel and promising targets to multi-epitopes vaccines against leptospirosis

and virulence-associated proteins. These proteins presented two (LIC13321-E1; LIC13321-E2) and four (LIC10715-E1, LIC10715-E2, LIC10715-E3, LIC10715-E4) predicted B-cell linear epitopes. Regarding the natural immunogenicity of predicted epitopes, about 8% and 25% of LG presented antibodies against LIC13321-E1 and LIC13321-E2, respectively. Moreover, while only 6% of LG presented antibodies against LIC10715-E2, other LIC10715 epitopes were specifically recognized by more than 25% of studied individuals. Conclusion: Four naturally immunogenic B-cell epitopes were identified in Leptospira thermolysins and will be evaluated about their protective potential to further compose novel multi-epitopes vaccines.

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Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes

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