桃红黄酮类化合物抗炎活性研究

G. Rani, Singara Charya Ma, M. Viswanadham, M. Thupurani
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引用次数: 1

摘要

炎症是机体组织对有害刺激(如病原体、受损细胞或刺激物)的复杂生物反应的一部分,是一种涉及免疫细胞、血管和分子介质的保护性反应。药用植物长期以来一直被认为是天然药物的潜在来源。本研究的目的是评价从水杨树中分离的化合物的抗炎活性。本研究采用体外和体内两种方法进行。用鸡蛋白蛋白对分离化合物进行体外抗炎活性筛选。在100μg/mL浓度下,化合物2和4对蛋白质变性的抑制作用分别高达90.5、84.1。化合物2和4在处理第4 h时对减小爪体积的活性分别为0.88±0.26、1.35±0.11。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiinflammatory activity of Flavonoids isolated from Rhus Mysorensis
Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. Medicinal plants have been long lastingly recognized as potential sources of natural drugs. The present study was framed to evaluate anti-inflammatory activity of the compounds isolated from Rhus mysorensis. The study was carried out using in vitro and in vivo methods. In vitro anti inflammatory activity of isolated compounds was screened using egg albumin. The inhibition of protein denaturation was found to be high 90.5, 84.1with the compounds 2 and 4 at 100μg/mL respectively. Compounds 2 and 4 found active in reducing the paw volume 0.88±0.26, 1.35±0.11 at fourth hour of treatment.
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