{"title":"硫酸壳聚糖/聚赖氨酸/转化生长因子-β1纳米颗粒的制备及其诱导骨髓间充质干细胞成软骨分化的能力:硫酸壳聚糖/聚赖氨酸/转化生长因子-β1纳米颗粒的制备及其诱导骨髓间充质干细胞成软骨分化的能力","authors":"Liu Fei-fei, Wang Qiu-wen, Ma Lie, Gao Chang-you","doi":"10.3724/SP.J.1105.2013.12425","DOIUrl":null,"url":null,"abstract":"采用共沉淀法制备了复合转化生长因子-1(TGF-1)的磺化壳聚糖/聚赖氨酸纳米粒子(SCS/PLL/TGF-1),研究了磺化壳聚糖的浓度对纳米粒子粒径和表面电位的影响.所得纳米微粒的粒径在240~290 nm、表面电位在-0.4~-1.3 mV之间可调.采用透射电子显微镜表征了磺化壳聚糖/聚赖氨酸(SCS/PLL)和SCS/PLL/TGF-1纳米粒子的形貌.通过体外骨髓间充质干细胞(BMSCs)培养实验,分别考察了SCS/PLL/TGF-1纳米粒子对BMSCs的增殖、氨基葡聚糖(GAGs)分泌和Ⅱ型胶原基因表达的影响.结果显示,相对于等量的SCS/PLL或同浓度的自由TGF-1,SCS/PLL/TGF-1纳米粒子可有效保护TGF-1的活性,促进BMSCs向软骨细胞分化,可望应用于软骨修复材料等领域的研究.","PeriodicalId":7133,"journal":{"name":"高分子学报","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2013-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PREPARATION OF SULFATED CHITOSAN/POLYLYSINE/TRANSFORM GROWTH FACTOR-β1 NANOPARTICLES AND THEIR ABILITY TO INDUCE CHONDROGENESIS DIFFERENTIATION OF BMSCs: PREPARATION OF SULFATED CHITOSAN/POLYLYSINE/TRANSFORM GROWTH FACTOR-β1 NANOPARTICLES AND THEIR ABILITY TO INDUCE CHONDROGENESIS DIFFERENTIATION OF\",\"authors\":\"Liu Fei-fei, Wang Qiu-wen, Ma Lie, Gao Chang-you\",\"doi\":\"10.3724/SP.J.1105.2013.12425\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"采用共沉淀法制备了复合转化生长因子-1(TGF-1)的磺化壳聚糖/聚赖氨酸纳米粒子(SCS/PLL/TGF-1),研究了磺化壳聚糖的浓度对纳米粒子粒径和表面电位的影响.所得纳米微粒的粒径在240~290 nm、表面电位在-0.4~-1.3 mV之间可调.采用透射电子显微镜表征了磺化壳聚糖/聚赖氨酸(SCS/PLL)和SCS/PLL/TGF-1纳米粒子的形貌.通过体外骨髓间充质干细胞(BMSCs)培养实验,分别考察了SCS/PLL/TGF-1纳米粒子对BMSCs的增殖、氨基葡聚糖(GAGs)分泌和Ⅱ型胶原基因表达的影响.结果显示,相对于等量的SCS/PLL或同浓度的自由TGF-1,SCS/PLL/TGF-1纳米粒子可有效保护TGF-1的活性,促进BMSCs向软骨细胞分化,可望应用于软骨修复材料等领域的研究.\",\"PeriodicalId\":7133,\"journal\":{\"name\":\"高分子学报\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2013-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"高分子学报\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.3724/SP.J.1105.2013.12425\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"高分子学报","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3724/SP.J.1105.2013.12425","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
PREPARATION OF SULFATED CHITOSAN/POLYLYSINE/TRANSFORM GROWTH FACTOR-β1 NANOPARTICLES AND THEIR ABILITY TO INDUCE CHONDROGENESIS DIFFERENTIATION OF BMSCs: PREPARATION OF SULFATED CHITOSAN/POLYLYSINE/TRANSFORM GROWTH FACTOR-β1 NANOPARTICLES AND THEIR ABILITY TO INDUCE CHONDROGENESIS DIFFERENTIATION OF