The epidemiology of stroke outcomes research: Illustration of an approach to outcomes methodology using racial/ethnic disparities in stroke

Stroke is associated with numerous health outcomes, the study of which is important for identifying best practices. However, it is equally important to understand the process to generating that knowledge. The methodological approach to stroke outcomes research is founded on first principles of epidemiological inquiry. These principles include defining the inquiry through a conceptual model; identifying and prioritizing the fundamental research questions; systematically addressing the research questions in order of importance; and exploring possible nuances to identified associations. To illustrate these principles in practice, the line of investigation into the reasons for racial/ethnic disparities in stroke mortality is used as a case study.