小児におけるフェノバルビタール血中濃度 S/D比と年齢の関係及び併用薬の影響

The effects of age and concurrent administration of antiepileptic drugs on phenobarbital serum concentration/dosage ratio in children were studied. The ratio of serum concentration/dosage for phenobarbital both without and with the concurrent administration of antiepileptic drugs was significantly correlated with the age of patients, and the ratio increased with the increase in the age of children. The ratio of patients who had taken valproate sodium and/or more than two kinds of anti-epileptics with phenobarbital washigher than that of patients had taken phenobarbital alone.Therefore, the patients who are taking valproate sodium and/or more than two kinds of anti-epileptics with phenobarbital is needed careful monitoring of phenobarbital serum concentrations because of their drug interaction.