脑芳香化酶调节胚胎斑马鱼的心脏功能

IF 2.8 Q1 VETERINARY SCIENCES

International Journal of Veterinary Science and Medicine Pub Date : 2019-01-02 DOI:10.1080/23144599.2019.1675287

Z. S. Ulhaq

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引用次数: 11

摘要

雌二醇(E2)是一种女性生殖激素，对心血管系统具有多效性作用。E2在脑和心肌细胞等局部生物合成中具有重要的生理和病理生理作用。E2的产生由芳香化酶(Aro)酶催化。在硬骨鱼中，两个Aro亚型在卵巢和脑中有明显的表达。本研究探讨脑阿罗蛋白(AroB)在调节心血管系统中的作用。arobmo介导的敲低降低了心室功能。此外，注射了AroB MO的胚胎显示出心力衰竭的迹象。暴露于E2可部分逆转AroB - MO引起的所有影响。综上所述，本研究证明了AroB在调节斑马鱼胚胎正常心血管功能中的作用。

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Brain aromatase modulates cardiac functions in embryonic zebrafish

ABSTRACT Oestradiol (E2) is known as a female reproductive hormone with pleiotropic effects on the cardiovascular system. Local E2 biosynthesis such as in the brain and myocardial cells have important physiological and pathophysiological roles. E2 production is catalysed by aromatase (Aro) enzyme. In teleost, two Aro isoforms are distinctly expressed in the ovary and brain. In this study, the role of brain Aro (AroB) in modulating cardiovascular system is investigated. AroB MO-mediated knockdown decreased ventricular functions. Moreover, embryos injected with AroB MO displays a sign in developing heart failure. All the effects caused by AroB MO were partially reversed by exposure to E2. Taken together, this study demonstrates the role of AroB in modulating normal cardiovascular function in zebrafish embryos.

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来源期刊

International Journal of Veterinary Science and Medicine VETERINARY SCIENCES-

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

24 weeks