信号转导和转录激活因子以及丝裂原活化蛋白激酶在脂肪细胞分化中的作用。

IF 4.8 4区物理与天体物理 Q2 PHYSICS, CONDENSED MATTER

Journal of Semiconductors Pub Date : 1999-10-30 DOI:10.1007/s000180050450

J Aubert, N Belmonte, C Dani

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引用次数: 0

摘要

信号转导和转录激活因子（STAT）家族成员和丝裂原活化蛋白激酶（MAPK）级联在细胞生长和分化的调控过程中发挥着重要作用。本综述将集中讨论这些途径在脂肪细胞发育过程中发挥的作用。脂肪细胞分化的正性和负性调控因子都会激活 STAT，从而提出了 STAT 通路可能在脂肪生成过程中发挥作用的假设。关于 p42/p44 MAPK 通路在脂肪细胞分化过程中的作用，最近有一些相互矛盾的报道。有人提出了几种分子机制来解释 MAPK 激活在脂肪细胞分化过程中的相反作用。

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Role of pathways for signal transducers and activators of transcription, and mitogen-activated protein kinase in adipocyte differentiation.

Members of the signal transducer and activator of transcription (STAT) family and the mitogen-activated protein kinase (MAPK) cascade play a major role in the regulation of cell growth and differentiation. This review concentrates on the role played by these pathways in the development of adipose cells. STATs are activated by both positive and negative modulators of adipocyte differentiation leading to the hypothesis that the STAT pathway may function in adipogenesis. The role of the p42/p44 MAPK pathway in adipocyte differentiation has recently been the subject of contradictory reports. Several molecular mechanisms are proposed to explain the opposing effects of MAPK activation in the programme of adipose cell differentiation.

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来源期刊

Journal of Semiconductors PHYSICS, CONDENSED MATTER-

CiteScore

6.70

自引率

9.80%

发文量

119

期刊介绍： Journal of Semiconductors publishes articles that emphasize semiconductor physics, materials, devices, circuits, and related technology.