伊维菌素®对非洲鲇鱼生物特征和器官生物标志物的影响

IF 0.9 4区生物学 Q3 MARINE & FRESHWATER BIOLOGY

Marine and Freshwater Behaviour and Physiology Pub Date : 2020-01-02 DOI:10.1080/10236244.2020.1734000

Ursula Ugonna Odo, Ifeanyi Christian Ezeoyili, I. Aguzie, S. N. Oluah, J. Madu, C. Nwani

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引用次数: 9

摘要

伊维菌素®(IVM)是人类和兽药中应用最广泛的抗寄生虫药物之一。本研究评估了IVM对非洲鲶鱼Clarias gariepinus生物特征和器官生物标志物的影响。鱼分别暴露于0.007、0.013和0.033 mg/L的IVM中，在第1、7、14、21天和恢复7天后采集脑、鳃和肝脏。病情因子和肝体指数呈混合趋势。组织中丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶活性呈浓度依赖性和时间依赖性显著升高。随着脑、肝、鳃脂质过氧化程度的升高，过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶活性下降。IVM诱导cariepinus幼鱼的生化、氧化应激和生物特征改变。因此，在水产养殖中使用该药物以控制鱼类寄生虫需要严格的预防措施。

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Effect of ivermectin® on biometric characteristics and organ biomarkers of African catfish Clarias gariepinus

ABSTRACT Ivermectin® (IVM) is one of the most widely used antiparasitic drugs in human and veterinary medicine. This study assesses the effect of IVM on biometric characteristics and organ biomarkers of African catfish, Clarias gariepinus. Fish were exposed to 0.007, 0.013 and 0.033 mg/L of IVM and the brain, gill and liver were sampled on days 1, 7, 14, 21 and after 7 – day recovery. A mixed trend was observed in the values of condition factor and hepatosomatic index. There was concentration- and duration-dependent significant increase in the activities of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in the tissues. While lipid peroxidation in the brain, liver and gill of the fish increased, activities of catalase, superoxide dismutase and glutathione peroxidase declined. IVM induced biochemical, oxidative stress, and biometric alterations in C. gariepinus juveniles. Thus, the use of the drug in aquaculture for the control of fish parasites requires stringent precautions.

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来源期刊

Marine and Freshwater Behaviour and Physiology 生物-海洋与淡水生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Marine and Freshwater Behaviour and Physiology is devoted to the publication of papers covering field and laboratory research into all aspects of the behaviour and physiology of all marine and freshwater animals within the contexts of ecology, evolution and conservation. As the living resources of the world’s oceans, rivers and lakes are attracting increasing attention as food sources for humans and for their role in global ecology, the journal will also publish the results of research in the areas of fisheries biology and technology where the behaviour and physiology described have clear links to the contexts mentioned above. The journal will accept for publication Research Articles, Reviews, Rapid Communications and Technical Notes (see Instructions for authors for details). In addition, Editorials, Opinions and Book Reviews (invited and suggested) will also occasionally be published. Suggestions to the Editor-In-Chief for Special Issues are encouraged and will be considered on an ad hoc basis. With the goal of supporting early career researchers, the journal particularly invites submissions from graduate students and post-doctoral researchers. In addition to recognising the time constraints and logistical limitations their research often faces, and their particular need for a prompt review process, accepted articles by such researchers will be given prominence within the journal (see Instructions for authors for details).