一些植物提取物和化合物的脂氧合酶抑制活性研究

O. Sacan, Emin Turhan
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引用次数: 11

摘要

脂氧化酶(LOXs,亚油酸:氧还原酶,E.C. 1.13.11.12)是一个非血红素含铁双加氧酶家族。LOXs与几种炎症相关疾病有关,如关节炎、哮喘、心血管、肾脏、皮肤和过敏性疾病、神经退行性疾病、癌症和代谢综合征。本研究考察了12种不同植物和12种不同化合物的乙醇提取物对LOX活性的抑制作用,这在保健领域具有重要的价值。本研究使用的植物提取物和化学物质均有抑制LOX的作用。提取物和化合物的酶抑制活性呈剂量依赖性增加。本研究的结果表明,植物提取物和化合物可以作为新型抗炎药物的潜在来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds
Lipoxygenases (LOXs, linoleate: oxygen reductase, E.C. 1.13.11.12) are a family of non-heme ironcontaining dioxygenases. LOXs are associated with several inflammation-related diseases such as arthritis, asthma, cardiovascular, kidney, skin and allergic diseases, neurodegenerative disorders, cancer and metabolic syndrome. In this study, the inhibitory effects of ethanolic extracts prepared from 12 different plants and 12 different chemical compounds were investigated on the activity of LOX which has an important value in the health area. All the plant extracts and chemical substances used in our study showed LOX inhibitory effect. The enzyme inhibitory activities of the extracts and chemical compounds were increasing in a dose-dependent manner. The results obtained in the present study indicate that plant extracts and chemical compounds examined can be a potential source of novel antiinflammatory therapeutics.
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