番槐叶柄甲醇提取物的植物化学筛选及抗抑郁活性评价

科技视界 Pub Date : 2018-12-31 DOI:10.33493/scivis.18.04.01

C. Lalremruati, C. Malsawmtluangi, H. Lalhlenmawia

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引用次数: 1

摘要

本研究的目的是确定附着物叶柄甲醇提取物中存在的植物成分和抗抑郁活性。初步的植物化学研究表明，石油醚提取物中含有脂肪和固定油，氯仿提取物中含有类固醇和三萜，甲醇提取物中含有黄酮类和单宁，水提取物中含有碳水化合物。在实验动物模型(大鼠)上，采用力游试验和悬尾试验对两种不同剂量的植物甲醇提取物进行了体内抗抑郁活性试验。丙咪嗪被用作该研究的标准药物。与对照组相比，200和400 mg/kg的甲醇提取物在静止期均显著降低(p<0.001)。因此，结果表明，甲醇提取物具有显著的抗抑郁活性。可能需要进一步的研究来了解实际的作用机制。

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Phytochemical screening and evaluation of antidepressant activity of methanolic extract of the spadix of Colocasia affinis Schott

The objective of this study was to determine the phytoconstituents present in successive extracts and the antidepressant activity of methanolic extract of the spadix of Colocasia affinis. The preliminary phytochemical investigation indicated the presence of fats and fixed oils, steroids and triterpenoids in petroleum ether extract, steroids and triterpenoids in chloroform extract, flavonoids and tannins in methanol extract and carbohydrates in the aqueous extract. An in vivo test for antidepressant activity was performed on the methanolic extract of the plant at two different doses using force swim test and tail suspension test on an experimental animal model (rat). Imipramine was used as a standard drug for the study. The methanolic extract at 200 and 400 mg/kg, produced significant reduction (p<0.001) in the immobility period when compared with that of control group animals in both the tests. Thus, the result indicates that the methanolic extract exhibited significantly good antidepressant activity. Further investigation may be needed to understand the actual mechanism of action.

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来源期刊

科技视界

自引率

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发文量

59577

期刊介绍： Science & Technology Vision is a science and technology journal supervised by the Shanghai Association for Science and Technology and sponsored by the Shanghai Science Writers Association. It takes grassroots science and education workers as readers, popularizes scientific knowledge, tracks hot issues in science and technology at home and abroad, pays attention to new developments, new technologies, and new achievements in the forefront of the science and technology community, adheres to the combination of theory and practice, popularization and exploration, integrates scientificity, knowledge, academicity, and foresight, and builds a platform and theoretical position for academic debate for the majority of science and technology workers. Science & Technology Vision has been fully included in "China National Knowledge Infrastructure", "Chinese Science and Technology Journal (VIP) Database", "Longyuan Journal Network", "Education Reading Network", and "Wanfang Database".