乙酰维甲酸NLC凝胶的制备及稳定性参数评价

IF 0.4 Q4 PHARMACOLOGY & PHARMACY

Asian Journal of Pharmaceutics Pub Date : 2021-07-22 DOI:10.22377/ajp.v15i2.4060

A. Kapoor

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引用次数: 0

摘要

目的:本研究旨在开发一种基于脂质的纳米载体，通过混合合适的脂质和表面活性剂，用于局部递送阿维a(一种用于治疗牛皮癣的维生素a类似物)，并根据监管指南评估各种配方的稳定性参数。方法:采用热均质法制备阿维素纳米脂质载体。通过改变表面活性剂(吐温80和十二烷基硫酸钠)的浓度来制备配方。制备的配方进行6个月的加速稳定性测试，稳定性样品的颜色、清晰度、均匀性、粘度、pH和zeta电位进行评估。结果:F3G具有较高的稳定性。结论:F3G的稳定性可能与表面活性剂的最佳浓度有关。

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Formulation and Assessment of Stability Parameters for Acitretin-Loaded NLC Gel

Purpose: The present investigation intended to develop a lipid-based nanocarrier for topical delivery of acitretin an analog of Vitamin A used in the management of psoriasis by mixing suitable lipids and blends of surfactants and to assess stability parameters for various formulations as per regulatory guidelines. Methods: Nanostructured lipid carriers of acitretin were prepared by the hot homogenization method. Formulations were prepared by varying the concentrations of surfactants (Tween 80 and sodium lauryl sulfate). Prepared formulations were subjected to accelerated stability testing for 6 months the stability samples were evaluated for color, clarity, homogeneity, viscosity, pH, and zeta potential. Results: Higher stability was observed in the F3G formulation. Conclusion: Higher stability in F3G formulation might be attributed to the presence of surfactants in optimum concentration.

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来源期刊

Asian Journal of Pharmaceutics PHARMACOLOGY & PHARMACY-

自引率

0.00%

发文量

期刊介绍： Character of the publications: -Pharmaceutics and Pharmaceutical Technology -Formulation Design and Development -Drug Discovery and Development Interface -Manufacturing Science and Engineering -Pharmacokinetics, Pharmacodynamics, and Drug Metabolism -Clinical Pharmacology, General Medicine and Translational Research -Physical Pharmacy and Biopharmaceutics -Novel Drug delivery system -Biotechnology & Microbiological evaluations -Regulatory Sciences