{"title":"慢性牙周炎和2型糖尿病患者龈沟液中生物标志物ykl-40和白细胞介素-6的水平","authors":"K. Kranti, N. Pramod, S. Ashwini, S. Naik","doi":"10.24327/ijrsr.2017.0805.0285","DOIUrl":null,"url":null,"abstract":"Elevated YKL – 40 levels are seen in patients with type 2 diabetes.Interleukin-6 is one of the most studied inflammatory markers in periodontal disease. Aim was to estimate and compare GCF levels of YKL-40 and Interleukin-6 in healthy, chronic periodontitis and type 2 diabetes mellitus patients with chronic periodontitis.82 patients were enrolled into the study and divided into three experimental groups healthy group, chronic periodontitis group and chronic periodontitis with type 2 diabetes mellitus group. Gingivalcrevicular fluid samples were collected and YKL-40 and Interleukin-6 were analysed by enzyme linked immunosorbent assay. The total amount of YKL-40 and IL-6 in GCF were higher in patients with periodontal tissue breakdown. Within the limits of this study it can be concluded that YKL-40 in GCF may reflect the inflammation of periodontitis and can be a useful marker for inflammation in periodontal diseases and type 2 diabetes mellitus.","PeriodicalId":14198,"journal":{"name":"International journal of recent scientific research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Levels of biomarker ykl-40 and interleukin-6 in gingival crevicular fluid in patients with chronic periodontitis and type 2 diabetes\",\"authors\":\"K. Kranti, N. Pramod, S. Ashwini, S. Naik\",\"doi\":\"10.24327/ijrsr.2017.0805.0285\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Elevated YKL – 40 levels are seen in patients with type 2 diabetes.Interleukin-6 is one of the most studied inflammatory markers in periodontal disease. Aim was to estimate and compare GCF levels of YKL-40 and Interleukin-6 in healthy, chronic periodontitis and type 2 diabetes mellitus patients with chronic periodontitis.82 patients were enrolled into the study and divided into three experimental groups healthy group, chronic periodontitis group and chronic periodontitis with type 2 diabetes mellitus group. Gingivalcrevicular fluid samples were collected and YKL-40 and Interleukin-6 were analysed by enzyme linked immunosorbent assay. The total amount of YKL-40 and IL-6 in GCF were higher in patients with periodontal tissue breakdown. Within the limits of this study it can be concluded that YKL-40 in GCF may reflect the inflammation of periodontitis and can be a useful marker for inflammation in periodontal diseases and type 2 diabetes mellitus.\",\"PeriodicalId\":14198,\"journal\":{\"name\":\"International journal of recent scientific research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of recent scientific research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24327/ijrsr.2017.0805.0285\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of recent scientific research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24327/ijrsr.2017.0805.0285","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Levels of biomarker ykl-40 and interleukin-6 in gingival crevicular fluid in patients with chronic periodontitis and type 2 diabetes
Elevated YKL – 40 levels are seen in patients with type 2 diabetes.Interleukin-6 is one of the most studied inflammatory markers in periodontal disease. Aim was to estimate and compare GCF levels of YKL-40 and Interleukin-6 in healthy, chronic periodontitis and type 2 diabetes mellitus patients with chronic periodontitis.82 patients were enrolled into the study and divided into three experimental groups healthy group, chronic periodontitis group and chronic periodontitis with type 2 diabetes mellitus group. Gingivalcrevicular fluid samples were collected and YKL-40 and Interleukin-6 were analysed by enzyme linked immunosorbent assay. The total amount of YKL-40 and IL-6 in GCF were higher in patients with periodontal tissue breakdown. Within the limits of this study it can be concluded that YKL-40 in GCF may reflect the inflammation of periodontitis and can be a useful marker for inflammation in periodontal diseases and type 2 diabetes mellitus.
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