接受血液透析的终末期肾病患者嗜酸性粒细胞增多

Kyoungha Kim, T. Chang, S. Yoon, Min-Young Lee, N. Lee, J. Won, Myungsook Chang
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摘要

目的:血液透析患者嗜酸性粒细胞增多已有报道。它与透析时对透析剂过敏和补体的过度激活有关。然而,其病因尚不清楚。此外,国内对血液透析患者嗜酸性粒细胞的研究也不足。因此,我们进行了这项回顾性研究,以了解血液透析患者血液嗜酸性粒细胞增多的患病率和可能的病因。方法:选取2013年1月至2015年12月在顺天香大学附属医院和国民健康保险服务中心(一山医院)住院的血液透析患者为研究对象。嗜酸性粒细胞绝对计数大于500/μL时为嗜酸性粒细胞增多。我们回顾性地回顾了患者关于寄生虫感染、其他恶性肿瘤和肾移植史的医疗记录。结果:在两个中心住院进行血液透析的2155例患者中,发现1057例(49%)患者有嗜酸性粒细胞增多症。对顺天香大学附属医院1199例患者的病历资料进行了调查。222名患者(16.8%)没有可识别和/或可能的病因。只有两名患者抱怨有瘙痒等症状。给予类固醇以控制症状,两名患者的嗜酸性粒细胞水平正常,类固醇停用。其他患者没有与嗜酸性粒细胞增多症相关的特殊症状,也没有服用类固醇等药物。未经特殊治疗的患者中有49%的嗜酸性粒细胞得到改善。结论:我们发现终末期肾病血液透析患者的嗜酸性粒细胞计数经常升高。然而,在大多数情况下,嗜酸性粒细胞增多与临床无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Eosinophilia in Patients with End Stage Renal Disease Undergoing Hemodialysis
Objective: Eosinophilia in patients on hemodialysis has already been reported. It has been associated with allergy to dialyzers and exaggerated activation of complement during hemodialysis. Its etiology, however, remains unknown. In addition, there are not enough studies on eosinophilia in patients on hemodialysis in Korea. Therefore, we performed this retrospective study to find out the prevalence and possible etiologic factors of blood eosinophilia in patients undergoing hemodialysis.Methods: Between January 2013 to December 2015, the patients hospitalized for hemodialysis at Soonchunhyang University Hospital and National Health Insurance Service Medical Center (Ilsan Hospital) were included in this study. Eosinophilia was defined when absolute eosinophil count was greater than 500/μL, respectively. We retrospectively reviewed the medical records of patients about parasite infection, other malignancies, and history of kidney transplantation.Results: Of the 2,155 patients hospitalized for hemodialysis at two centers, 1,057 patients (49%) were found to have eosinophilia. We investigated 1,199 patients’ information (Soonchunhyang University Hospital) by the medical records. Two hundred two patients (16.8%) had no identifiable and/or possible causes. Only two patients complained of symptoms such as itching. Steroids were administered to control symptoms, and both patients had normal eosinophil levels, and steroids were discontinued. Other patients did not complain of specific symptoms associated with eosinophilia and did not take medication such as steroids. Eosinophilia was improved in 49% of patients without special treatments.Conclusion: We found that the eosinophil counts in patients with end stage renal disease on hemodialysis were frequently elevated. However, in most cases, eosinophilia was not clinically relevant.
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