{"title":"不同温度下泰洛菌素在纯溶剂和混合溶剂中的溶解度和溶液热力学","authors":"Yanmin Shen, Wenju Liu, Zehua Bao, Zhanhu Guo","doi":"10.30919/esmm5f233","DOIUrl":null,"url":null,"abstract":"Thermodynamic data of drug is important to industrial design and industrial application. In this paper, solubility data of tylosin in pure solvents and acetone +water mixture solvents were experimentally determined from 279.75 K to 323.15 K. The experiment results indicated that solubility of tylosin in pure solvents gradually decreased and followed this order: chloroform > buty lacetate > acetonitrile > tetrahydrofuran > acetone > benzene > n-butanol > ethy lacetate > n-propanol > ethanol > methanol > water, and solubility gradually decreased with water increasing in water+acetone mixture solvents. Moreover, experimental solubility increased with temperature increasing except for water(x ≥ c","PeriodicalId":11851,"journal":{"name":"ES Materials & Manufacturing","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Solubility and Solution Thermodynamics of Tylosin in Pure Solvents and Mixed Solvents at Various Temperatures\",\"authors\":\"Yanmin Shen, Wenju Liu, Zehua Bao, Zhanhu Guo\",\"doi\":\"10.30919/esmm5f233\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Thermodynamic data of drug is important to industrial design and industrial application. In this paper, solubility data of tylosin in pure solvents and acetone +water mixture solvents were experimentally determined from 279.75 K to 323.15 K. The experiment results indicated that solubility of tylosin in pure solvents gradually decreased and followed this order: chloroform > buty lacetate > acetonitrile > tetrahydrofuran > acetone > benzene > n-butanol > ethy lacetate > n-propanol > ethanol > methanol > water, and solubility gradually decreased with water increasing in water+acetone mixture solvents. Moreover, experimental solubility increased with temperature increasing except for water(x ≥ c\",\"PeriodicalId\":11851,\"journal\":{\"name\":\"ES Materials & Manufacturing\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ES Materials & Manufacturing\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30919/esmm5f233\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ES Materials & Manufacturing","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30919/esmm5f233","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
摘要
药物的热力学数据对工业设计和工业应用具有重要意义。本文在279.75 K ~ 323.15 K范围内实验测定了泰络素在纯溶剂和丙酮+水混合溶剂中的溶解度数据。实验结果表明，泰络素在纯溶剂中的溶解度逐渐降低，其溶解度依次为:氯仿>乳酸丁酯>乙腈>四氢呋喃>丙酮>苯>正丁醇>乳酸乙酯>正丙醇>乙醇>甲醇>水，在水+丙酮混合溶剂中溶解度随水的增加而逐渐降低。除水(x≥c)外，实验溶解度随温度升高而升高
Solubility and Solution Thermodynamics of Tylosin in Pure Solvents and Mixed Solvents at Various Temperatures
Thermodynamic data of drug is important to industrial design and industrial application. In this paper, solubility data of tylosin in pure solvents and acetone +water mixture solvents were experimentally determined from 279.75 K to 323.15 K. The experiment results indicated that solubility of tylosin in pure solvents gradually decreased and followed this order: chloroform > buty lacetate > acetonitrile > tetrahydrofuran > acetone > benzene > n-butanol > ethy lacetate > n-propanol > ethanol > methanol > water, and solubility gradually decreased with water increasing in water+acetone mixture solvents. Moreover, experimental solubility increased with temperature increasing except for water(x ≥ c
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