三吡啶基双核Cu(II)配合物的超分子组装及其DNA对接研究

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Supramolecular Chemistry Pub Date : 2021-09-02 DOI:10.1080/10610278.2022.2057228

Sanobar Naaz, R. A. Laskar, Sk Khalid Rahaman, S. Wabaidur, M. Siddiqui, M. Islam, Md. Maidul Islam, Mohammad Hedayetullah Mir, S. M. Alam

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引用次数: 2

摘要

摘要:采用慢蒸发法，在单釜技术下合成了一种以三吡啶为基础的双核Cu(II)配合物，分子式为[Cu2(tpy)2(muco)(NO3)2]， (1) (type = 2,2 ';6 '，2 " -三吡啶和H2-muco =反式，反式粘膜酸)。一天后得到蓝色的扭曲八面体晶体。合成的化合物已通过元素分析和单晶x射线衍射(SCXRD)技术进行了表征。赫希菲尔德表面分析已经被用来研究分子间相互作用的性质和晶体状态下化合物的堆积模式。对接研究发现，金属配合物与DNA主槽结合，配体的规划芳香吡啶环部分插入碱基对。

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Supramolecular Assembly of a Terpyridyl based Binuclear Cu(II) Complex and its DNA Docking Study

ABSTRACT A terpyridyl-based binuclear Cu(II) complex, formulated as [Cu2(tpy)2(muco)(NO3)2], (1) (typ = 2,2’;6’,2”-terpyridine and H2-muco = trans, trans-muconic acid) was synthesised in a single pot technique using slow evaporation method. Blue coloured distorted octahedral-shaped crystals were obtained after a day. Synthesised compound has been characterised by elemental analysis as well as single crystal X-ray diffraction (SCXRD) techniques. Hirshfeld surface analysis has been explored to check out the nature of intermolecular interactions and packing modes of compounds in the crystalline state. From the docking study, it has been found that the metal complex bind to the major groove of DNA and the planner aromatic pyridine ring of the ligand partially intercalate into the base pairs.

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来源期刊

Supramolecular Chemistry 化学-化学综合

CiteScore

3.60

自引率

3.00%

发文量

审稿时长

2.7 months

期刊介绍： Supramolecular Chemistry welcomes manuscripts from the fields and sub-disciplines related to supramolecular chemistry and non-covalent interactions. From host-guest chemistry, self-assembly and systems chemistry, through materials chemistry and biochemical systems, we interpret supramolecular chemistry in the broadest possible sense. Interdisciplinary manuscripts are particularly encouraged. Manuscript types include: high priority communications; full papers; reviews, and; Methods papers, techniques tutorials highlighting procedures and technologies that are important to the field. We aim to publish papers in a timely fashion and as soon as a paper has been accepted and typeset it will be published in electronic form on the Latest articles section of the website. The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field. Under normal circumstances, Supramolecular Chemistry does not consider manuscripts that would be more suitable in a highly specialized journal. This includes, but is not limited to, those based mostly or exclusively on topics such as solid state/X-ray structures, computational chemistry, or electrochemistry. . The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field.