与表皮生长因子受体抑制剂相关的皮肤不良事件:跨学科问题的当前概念

A. Polonskaia, E. Shatokhina, L. Kruglova
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引用次数: 4

摘要

表皮生长因子受体抑制剂(EGFR)具有高比例的类别特异性皮肤不良事件。对皮肤不良事件的支持治疗可降低其严重程度,最大限度地减少剂量递减/停止靶向治疗的需要,提高抗癌治疗的承诺和患者的生活质量。肿瘤学家和皮肤科医生之间密切的跨学科合作是成功管理EGFR患者的关键。本文重点介绍了目前的分类方法,egfr相关皮肤不良事件的发病机制和临床过程的概念,当前和有希望的预防和治疗策略来管理这些不良事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dermatologic adverse events associated with epidermal growth factor receptor inhibitors: current concepts of interdisciplinary problem
Epidermal growth factor receptor inhibitors (EGFR) have a high rate of class-specific dermatologic adverse events. Supportive treatment of dermatologic adverse events decreases their severity, minimizes the need for dose de-escalation / discontinuation of targeted therapy, improves commitment to anticancer treatment and patient’s quality of life. Close interdisciplinary cooperation between oncologists and dermatologists is a key to the successful management of patients treated with EGFR. This article highlights current approaches to classification, concepts of pathogenesis and clinical course of EGFR-associated dermatologic adverse events, current and promising prophylactic and therapeutic strategies to manage these adverse events.
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