Umer Farooq, Faraz Khan, Irfan Ahmad, Muhammad Nawaz, S. H. Changazi, Muhammad Imran
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引用次数: 0
摘要
背景:尿道狭窄复发是最常见和最麻烦的并发症,大多数狭窄在光学内尿道切开术后复发。本研究的目的是确定直接视觉内尿道切开术(DVIU)后口服类固醇治疗在减少尿道狭窄复发中的作用。方法:这是一项随机对照试验,于2018年1月至2021年3月在拉瓦尔品第武装部队泌尿外科研究所进行。本组共纳入尿道狭窄≤2 cm男性患者180例。排除外伤性狭窄、吻合口尿道成形术后狭窄、神经源性膀胱和类固醇摄入史的患者。将患者随机分为两组,A组患者给予泼尼松龙口服(6 mg片,每日2次,连用4周),B组为对照组。随访12个月,观察狭窄复发情况。结果:A组患者平均年龄44.38±8.03岁,B组患者平均年龄46.64±6.66岁。A组平均狭窄长度为0.93±0.26 cm, B组平均狭窄长度为0.95±0.27 cm。A组(口服类固醇组)狭窄复发18例(20.0%),B组(不口服类固醇组)狭窄复发42例(46.67%),p值为0.0001。结论:内尿道切开术后口服强的松龙治疗可有效降低尿道狭窄复发率。关键词:口服,复发,类固醇,尿道狭窄。
Role of Steroids in Reducing Recurrence of Urethral Stricture after Direct Vision Internal Urethrotomy
Background: Recurrence of urethral strictures is the most frequent and bothersome complication, with majority of stricturesrecurring after optical internal urethrotomy. The objective of this study was to establish the role of oral steroid therapy after direct vision internal urethrotomy (DVIU) in minimizing recurrence of urethral stricture.
Methodology: It was a randomized controlled trial carried out at Armed Forces Institute of Urology, Rawalpindi from January 2018 to March 2021. A total of 180 male patients with urethral stricture of ≤2 cm were included. Patients with traumatic stricture, post-anastomotic urethroplasty strictures, neurogenic bladder and history of steroid intake were excluded. Patients were randomly categorized into two groups i.e. Group A patients were given oral prednisolone (6 mg tablet twice daily for 4 weeks) while group B was control group. Patients were followed up to 12 months for recurrence of stricture.
Results: The mean age of patients in group A was 44.38 ± 8.03 years while in group B was 46.64 ± 6.66 years. The mean length of stricture in group A was 0.93 ± 0.26 cm and in group B was 0.95 ± 0.27 cm. Recurrence of stricture was seen in 18 (20.0%) patients in group A (oral steroids group) and 42 (46.67%) patients in group B (no oral steroids) with p-value of 0.0001.
Conclusion: Oral prednisolone therapy after internal urethrotomy waseffective in decreasing the rate of recurrence of urethral stricture.
Keywords: Oral, Recurrence, Steroid, Urethral Stricture.