评价急诊高血压危重患者使用艾司洛尔的有效性和安全性

Q4 Medicine

Sklifosovsky Journal Emergency Medical Care Pub Date : 2023-06-02 DOI:10.24884/2072-6716-2023-24-2-33-39

N. I. Gaponova

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引用次数: 0

摘要

对94例合并或不合并高血压危重症患者进行院前急救阶段给予艾司洛尔的有效性和安全性的观察。艾司洛尔独特的药代动力学特性使我们在静脉注射的最初几分钟内动脉张力显著降低，同时降压作用持续到20分钟，消除半衰期为9分钟。根据初始血流动力学指标和高血压危象并发症选择艾司洛尔剂量。为了评价本研究的有效性和安全性，测量了以下指标:收缩压、舒张压、心率、心电图和SpO2、呼吸功能监测。

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Evaluation of the efficiency and safety of Esmolol in patients, who suffers from hypertensic crisis, within the conditions of emergency medical care

In 94 patients, suffering from complicated or uncomplicated hypertensic crisis, the efficiency and safety of esmolol administration in pre-hospital stage of emergency medical care was examined. Unique pharmacokinetics of esmolol allow us to achieve significant arterial tension decrease during the first minutes of the intravenous injection, meanwhile antihypertensive effect increases till 20 minutes and elimination half-life is 9 minutes. Esmolol dosage was selected depending on initial hemodynamic indicators and hypertensic crisis complications. In order to evaluate efficiency and safety in this research the following indicators were measured: sistolic blood pressure, diastolic blood pressure, heart rate, electrocardiogram and SpO2 , respiratory function monitoring.

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来源期刊

Sklifosovsky Journal Emergency Medical Care Medicine-Emergency Medicine

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The Journal "Neotlozhnaia meditsinskaia pomoshch" (parallel titles: Zhurnal im. N.V. Sklifosovskogo "Neotlozhnai︠a︡ medit︠s︡inskai︠a︡ pomoshch", "Sklifosovsky Journal of Emergency Medical Care") seeks to publish original research articles, literature reviews, case reports, brief reports on clinical practice, and other suitable material submitted by professionals involved in the diagnosis and treatment of acute medical and surgical conditions.