Ana Cardeña Gutiérrez, D. Mínguez, Mónica Esteban García, Elena García García, X. M. Rubio
{"title":"免疫相关的毒性:并不总是罪魁祸首","authors":"Ana Cardeña Gutiérrez, D. Mínguez, Mónica Esteban García, Elena García García, X. M. Rubio","doi":"10.47363/jcbr/2021(3)134","DOIUrl":null,"url":null,"abstract":"He was admitted into the emergency room on September 2020 due to a three-day grade 3 emesis and rapidly progressive weight loss. Complementary studies showed grade 3 immune-related gastritis, with great response to corticosteroids within 2 days of treatment. He received metilprednisolone 1mg/kg/day for one month, and then, we started corticosteroid tapering. However, we could not lower the dose from prednisone 30 mg/day because grade 2 emesis and grade 2 diarrhea appeared. We considered starting Infliximab 5 mg/kg for corticosteroid refractory immunerelated toxicity(irAEs) but we needed an endoscopic study first, as ESMO guidelines recommend [1]. Pre-antiTNF screening with viral serologies an IGRA was negative.","PeriodicalId":15099,"journal":{"name":"Journal of Biomedical and Clinical Research","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immune-Related Toxicity: Not always the Culprit\",\"authors\":\"Ana Cardeña Gutiérrez, D. Mínguez, Mónica Esteban García, Elena García García, X. M. Rubio\",\"doi\":\"10.47363/jcbr/2021(3)134\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"He was admitted into the emergency room on September 2020 due to a three-day grade 3 emesis and rapidly progressive weight loss. Complementary studies showed grade 3 immune-related gastritis, with great response to corticosteroids within 2 days of treatment. He received metilprednisolone 1mg/kg/day for one month, and then, we started corticosteroid tapering. However, we could not lower the dose from prednisone 30 mg/day because grade 2 emesis and grade 2 diarrhea appeared. We considered starting Infliximab 5 mg/kg for corticosteroid refractory immunerelated toxicity(irAEs) but we needed an endoscopic study first, as ESMO guidelines recommend [1]. Pre-antiTNF screening with viral serologies an IGRA was negative.\",\"PeriodicalId\":15099,\"journal\":{\"name\":\"Journal of Biomedical and Clinical Research\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomedical and Clinical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47363/jcbr/2021(3)134\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomedical and Clinical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47363/jcbr/2021(3)134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
He was admitted into the emergency room on September 2020 due to a three-day grade 3 emesis and rapidly progressive weight loss. Complementary studies showed grade 3 immune-related gastritis, with great response to corticosteroids within 2 days of treatment. He received metilprednisolone 1mg/kg/day for one month, and then, we started corticosteroid tapering. However, we could not lower the dose from prednisone 30 mg/day because grade 2 emesis and grade 2 diarrhea appeared. We considered starting Infliximab 5 mg/kg for corticosteroid refractory immunerelated toxicity(irAEs) but we needed an endoscopic study first, as ESMO guidelines recommend [1]. Pre-antiTNF screening with viral serologies an IGRA was negative.
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